Protein profile

KP13_03880

Heat shock protein hspQ

Genome: KpKP13

Gene: hspQ AHE45373.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR50
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Amino acids 105
Annotations 3
Features 14
PDB binders 0
Druggability 0.221

Overview

Basic information about this protein and its source genome.

Accession
KP13_03880
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hspQ AHE45373.1
Status
annotated
Amino acids
105
Structure source
AlphaFold + ColabFold
GO
GO:0009408 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.221
Structure A0A0H3GR50
Pocket Pocket 3
P2Rank
Structure A0A0H3GR50
Pocket No pockets
ColabFold model
FPocket 0.012 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 111 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009408 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
4 102 NCBIfam TIGR02097 heat shock protein HspQ
4 102 InterPro IPR011722 Hemimethylated DNA-binding domain
5 96 Pfam PF08755 Hemimethylated DNA-binding protein YccV like
5 96 InterPro IPR011722 Hemimethylated DNA-binding domain
1 105 Hamap MF_01194 Heat shock protein HspQ [hspQ].
1 105 InterPro IPR022866 Heat shock protein HspQ
70 105 MobiDBLite mobidb-lite consensus disorder prediction
74 88 MobiDBLite mobidb-lite consensus disorder prediction
3 102 SMART SM00992 YccV_like_2_a
3 102 InterPro IPR011722 Hemimethylated DNA-binding domain
4 95 SUPERFAMILY SSF141255 YccV-like
4 95 InterPro IPR036623 Hemimethylated DNA-binding domain superfamily
1 105 Gene3D G3DSA:2.30.30.390 -
1 105 InterPro IPR036623 Hemimethylated DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR50
AlphaFold — — full sequence — Viewing
ColabFold KP13_03880
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.221