Protein profile

KP13_03873

Cell division inhibitor sulA

Genome: KpKP13

Gene: sulA AHE45380.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GV56
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Amino acids 169
Annotations 4
Features 15
PDB binders 0
Druggability 0.566

Overview

Basic information about this protein and its source genome.

Accession
KP13_03873
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sulA AHE45380.1
Status
annotated
Amino acids
169
Structure source
AlphaFold + ColabFold
GO
GO:0009432 An error-prone process for repairing damaged microbial DNA. GO:0051782 Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
78.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.566
Structure A0A0H3GV56
Pocket Pocket 5
P2Rank 0.718
Structure A0A0H3GV56
Pocket Pocket 1
ColabFold model
FPocket 0.497 · Pocket 2
P2Rank 0.713 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 87 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0009432 An error-prone process for repairing damaged microbial DNA.
  • GO:0051782 Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
  • GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
11 168 PANTHER PTHR35369 BLR3025 PROTEIN-RELATED
6 119 Pfam PF03846 Cell division inhibitor SulA
6 119 InterPro IPR004596 Cell division suppressor protein, SulA
2 169 NCBIfam TIGR00623 SOS-induced cell division inhibitor SulA, enterobacterial type
2 169 InterPro IPR047696 Cell division inhibitor SulA, enterobacterial type
31 146 FunFam G3DSA:3.40.50.300:FF:000417 Cell division inhibitor SulA
1 169 PIRSF PIRSF003093 SulA
1 169 InterPro IPR004596 Cell division suppressor protein, SulA
31 147 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
31 147 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
31 146 Gene3D G3DSA:3.40.50.300 -
31 146 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
5 24 MobiDBLite mobidb-lite consensus disorder prediction
1 169 Hamap MF_01179 Cell division inhibitor SulA [sulA].
1 169 InterPro IPR047696 Cell division inhibitor SulA, enterobacterial type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GV56
AlphaFold — — full sequence — Viewing
ColabFold KP13_03873
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.137
1 0.012
3 0.0
12 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.12 0.718