Protein profile

KP13_03870

hypothetical protein

Genome: KpKP13

Gene: AHE45383.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQT0
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Amino acids 150
Annotations 4
Features 10
PDB binders 0
Druggability 0.142

Overview

Basic information about this protein and its source genome.

Accession
KP13_03870
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45383.1
Status
annotated
Amino acids
150
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
54.73
DEG E-value
9.85e-53
Localization
Cytoplasmic
ColabFold pLDDT
94.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.142
Structure A0A0H3GQT0
Pocket Pocket 14
P2Rank 0.035
Structure A0A0H3GQT0
Pocket Pocket 1
ColabFold model
FPocket 0.869 · Pocket 4
P2Rank 0.036 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 129 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
98 150 Gene3D G3DSA:1.10.1220.10 -
98 150 InterPro IPR013321 Arc-type ribbon-helix-helix
1 148 Hamap MF_01073 Macrodomain Ter protein [matP].
1 148 InterPro IPR009390 Macrodomain Ter protein, MatP
1 89 Gene3D G3DSA:1.20.1270.380 -
1 89 InterPro IPR038339 MatP, N-terminal domain superfamily
88 147 Pfam PF17414 MatP C-terminal ribbon-helix-helix domain
88 147 InterPro IPR035375 MatP, C-terminal ribbon-helix-helix domain
2 85 Pfam PF06303 MatP N-terminal domain
2 85 InterPro IPR035087 MatP, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQT0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03870
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.2 0.01