Protein profile

KP13_03864

Paraquat-inducible protein A

Genome: KpKP13

Gene: pqiA AHE45389.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQS5
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Amino acids 405
Annotations 1
Features 32
PDB binders 0
Druggability 0.988

Overview

Basic information about this protein and its source genome.

Accession
KP13_03864
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pqiA AHE45389.1
Status
annotated
Amino acids
405
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.988
Structure A0A0H3GQS5
Pocket Pocket 4
P2Rank 0.623
Structure A0A0H3GQS5
Pocket Pocket 1
ColabFold model
FPocket 0.584 · Pocket 13
P2Rank 0.663 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 107 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
82 105 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
290 312 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
333 354 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 183 Pfam PF04403 Paraquat-inducible protein A
32 183 InterPro IPR007498 Intermembrane transport protein PqiA-like
236 391 Pfam PF04403 Paraquat-inducible protein A
236 391 InterPro IPR007498 Intermembrane transport protein PqiA-like
34 56 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
169 239 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
333 355 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 391 NCBIfam TIGR00155 PqiA/YebS family transporter subunit
1 391 InterPro IPR005219 Intermembrane transport protein PqiA-like, proteobacteria
106 116 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
36 55 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
117 139 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
118 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 405 PANTHER PTHR30462 UNCHARACTERIZED
140 144 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
238 260 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
313 332 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
384 405 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
145 167 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
360 383 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
360 382 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
145 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
287 312 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
261 286 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
56 81 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
355 359 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 35 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
240 260 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 105 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQS5
AlphaFold — — full sequence — Viewing
ColabFold KP13_03864
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.988
17 0.27
10 0.21

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.74 0.524
2 3.46 0.125
3 2.36 0.062
4 2.13 0.049
5 1.36 0.016