Protein profile

KP13_03858

FMN reductase

Genome: KpKP13

Gene: AHE45395.1 ssuE Structure source: AlphaFold + ColabFold UniProt A0A0H3GR30
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Amino acids 201
Annotations 3
Features 9
PDB binders 0
Druggability 0.696

Overview

Basic information about this protein and its source genome.

Accession
KP13_03858
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45395.1 ssuE
Status
annotated
Amino acids
201
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008752 Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates. GO:0046306 The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.59

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.696
Structure A0A0H3GR30
Pocket Pocket 6
P2Rank
Structure A0A0H3GR30
Pocket No pockets
ColabFold model
FPocket 0.835 · Pocket 11
P2Rank 0.118 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 85 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0008752 Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates.
  • GO:0046306 The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
11 189 PANTHER PTHR43408 FMN REDUCTASE (NADPH)
11 184 Gene3D G3DSA:3.40.50.360 -
11 184 InterPro IPR029039 Flavoprotein-like superfamily
12 181 NCBIfam TIGR03567 NADPH-dependent FMN reductase
12 181 InterPro IPR020048 NADPH-dependent FMN reductase, SsuE
11 178 SUPERFAMILY SSF52218 Flavoproteins
11 178 InterPro IPR029039 Flavoprotein-like superfamily
11 151 Pfam PF03358 NADPH-dependent FMN reductase
11 151 InterPro IPR005025 NADPH-dependent FMN reductase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR30
AlphaFold — — full sequence — Viewing
ColabFold KP13_03858
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.696