Protein profile

KP13_04173

Serine transporter

Genome: KpKP13

Gene: AHE45404.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR22

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Amino acids 429

Annotations 2

Features 39

PDB binders 0

Druggability 0.724

Overview

Basic information about this protein and its source genome.

Accession: KP13_04173
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE45404.1
Status: annotated
Amino acids: 429
Structure source: AlphaFold + ColabFold

GO:0003333 The process in which an amino acid is transported across a membrane. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 54.286
DEG E-value: 1.6e-163
Localization: CytoplasmicMembrane
ColabFold pLDDT: 89.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.724

Structure A0A0H3GR22

Pocket Pocket 1

P2Rank 0.876

Structure A0A0H3GR22

Pocket Pocket 1

ColabFold model

FPocket 0.903 · Pocket 11

P2Rank 0.893 · Pocket 1

Core conservation Accessory gene

Roary core

CoreCruncher accessory

Gut microbiome 126 / 4744 genomes with a hit

Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0003333 The process in which an amino acid is transported across a membrane.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

39 records

Show feature table

Start	End	DB	Term	Name
343	365	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
365	369	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
157	167	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
300	323	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
100	120	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
300	322	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	23	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
274	299	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
205	227	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	428	PANTHER	PTHR35334	SERINE TRANSPORTER
4	428	InterPro	IPR018227	Amino acid/polyamine transporter 2
189	207	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
429	429	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23	429	Gene3D	G3DSA:1.20.1740.10	Amino acid/polyamine transporter I
410	428	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
405	427	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
68	99	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
370	389	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
24	43	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
370	392	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
208	232	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
30	333	Pfam	PF03222	Tryptophan/tyrosine permease family
30	333	InterPro	IPR018227	Amino acid/polyamine transporter 2
44	48	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
390	409	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
168	188	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
49	67	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
102	124	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
121	139	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
168	190	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
47	66	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
344	364	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
140	156	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
24	43	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
139	156	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
255	274	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
233	252	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
324	343	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
253	273	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GR22	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04173	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.724

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	13.85	0.701
2	6.95	0.359
3	2.56	0.073
4	2.09	0.047
5	1.58	0.024

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
11				0.903

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	10.77	0.578
2	4.66	0.203
3	4.42	0.186
4	2.55	0.072
5	2.24	0.055