Protein profile

KP13_04178

Beta-lactamase-like protein

Genome: KpKP13

Gene: AHE45409.1 Structure source: AlphaFold + ColabFold UniProt A0A0N6WZQ7
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Amino acids 213
Annotations 3
Features 7
PDB binders 0
Druggability 0.38

Overview

Basic information about this protein and its source genome.

Accession
KP13_04178
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45409.1
Status
annotated
Amino acids
213
Structure source
AlphaFold + ColabFold
EC
1.6.3.-
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.38
Structure A0A0N6WZQ7
Pocket Pocket 5
P2Rank 0.084
Structure A0A0N6WZQ7
Pocket Pocket 1
ColabFold model
FPocket 0.343 · Pocket 1
P2Rank 0.084 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
24 156 PANTHER PTHR32145 DIFLAVIN FLAVOPROTEIN A 2-RELATED
19 210 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase
19 210 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
21 205 SMART SM00849 Lactamase_B_5a
21 205 InterPro IPR001279 Metallo-beta-lactamase
4 211 Gene3D G3DSA:3.60.15.10 -
4 211 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0N6WZQ7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04178
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.38

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.17 0.052
2 1.65 0.027
3 1.5 0.021