Protein profile

KP13_04183

Hedgehog signaling domain-containing protein

Genome: KpKP13

Gene: AHE45414.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQP5
Export view
Amino acids 211
Annotations 4
Features 15
PDB binders 0
Druggability 0.279

Overview

Basic information about this protein and its source genome.

Accession
KP13_04183
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45414.1
Status
annotated
Amino acids
211
Structure source
AlphaFold + ColabFold
GO
GO:0046872 Binding to a metal ion. GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.257
DEG E-value
1.4700000000000001e-123
Localization
Unknown
ColabFold pLDDT
82.99

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.279
Structure A0A0H3GQP5
Pocket Pocket 8
P2Rank 0.731
Structure A0A0H3GQP5
Pocket Pocket 1
ColabFold model
FPocket 0.633 · Pocket 9
P2Rank 0.819 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 121 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0046872 Binding to a metal ion.
  • GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 59 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 59 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 59 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
104 211 CDD cd14844 Zn-DD-carboxypeptidase_like
27 211 PANTHER PTHR37425 -
27 211 InterPro IPR010275 Protein of unknown function DUF882
92 211 Gene3D G3DSA:3.30.1380.10 -
92 211 InterPro IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
60 211 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
95 211 SUPERFAMILY SSF55166 Hedgehog/DD-peptidase
95 211 InterPro IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
62 211 Pfam PF05951 Bacterial protein of unknown function (DUF882)
62 211 InterPro IPR010275 Protein of unknown function DUF882
1 38 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQP5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04183
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.279

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.29 0.498