Protein profile

KP13_04187

Chromosome partition protein mukF

Genome: KpKP13

Gene: mukF AHE45418.1 Structure source: AlphaFold + ColabFold UniProt A6T714
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Amino acids 440
Annotations 3
Features 22
PDB binders 0
Druggability 0.889

Overview

Basic information about this protein and its source genome.

Accession
KP13_04187
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mukF AHE45418.1
Status
annotated
Amino acids
440
Structure source
AlphaFold + ColabFold
GO
GO:0005509 Binding to a calcium ion (Ca2+). GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.182
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.889
Structure A6T714
Pocket Pocket 1
P2Rank 0.025
Structure A6T714
Pocket Pocket 1
ColabFold model
FPocket 0.625 · Pocket 2
P2Rank 0.059 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 142 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005509 Binding to a calcium ion (Ca2+).
  • GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
  • GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
119 311 Gene3D G3DSA:1.20.58.590 Chromosome partition protein MukF, middle domain
119 311 InterPro IPR036141 MukF, middle domain superfamily
121 281 Pfam PF17192 MukF middle domain
121 281 InterPro IPR033440 Chromosome partition protein MukF, middle domain
8 118 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
8 118 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 440 PIRSF PIRSF018282 MukF
1 440 InterPro IPR005582 Chromosome partition protein MukF
342 438 CDD cd16337 MukF_C
342 438 InterPro IPR033441 Chromosome partition protein MukF, C-terminal domain
1 440 Hamap MF_01803 Chromosome partition protein MukF [mukF].
24 118 Gene3D G3DSA:1.10.10.10 -
24 118 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
119 281 SUPERFAMILY SSF140570 MukF C-terminal domain-like
119 281 InterPro IPR036141 MukF, middle domain superfamily
353 440 Gene3D G3DSA:1.10.225.40 -
353 440 InterPro IPR038198 MukF, C-terminal domain superfamily
13 328 CDD cd16335 MukF_N
3 117 Pfam PF03882 MukF winged-helix domain
3 117 InterPro IPR033439 Chromosome partition protein MukF, winged-helix domain
283 440 Pfam PF17193 MukF C-terminal domain
283 440 InterPro IPR033441 Chromosome partition protein MukF, C-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A6T714
AlphaFold — — full sequence — Viewing
ColabFold KP13_04187
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.889
3 0.376

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.08 0.047