Protein profile

KP13_04196

Beta-lactamase-like domain-containing protein

Genome: KpKP13

Gene: AHE45427.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMB1
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Amino acids 756
Annotations 3
Features 50
PDB binders 0
Druggability 0.999

Overview

Basic information about this protein and its source genome.

Accession
KP13_04196
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45427.1
Status
annotated
Amino acids
756
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030420 The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.999
Structure A0A0H3GMB1
Pocket Pocket 65
P2Rank 0.919
Structure A0A0H3GMB1
Pocket Pocket 1
ColabFold model
FPocket 0.928 · Pocket 45
P2Rank 0.896 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 60 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0030420 The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

50 records
Show feature table
Start End DB Term Name
301 305 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
303 325 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
68 720 NCBIfam TIGR00361 DNA internalization-related competence protein ComEC/Rec2
68 720 InterPro IPR004797 Competence protein ComEC/Rec2
502 666 CDD cd07731 ComA-like_MBL-fold
502 666 InterPro IPR035681 ComA-like, MBL domain
226 248 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
223 406 NCBIfam TIGR00360 ComEC/Rec2-related protein
223 406 InterPro IPR004477 ComEC/Rec2-related protein
1 40 Phobius SIGNAL_PEPTIDE Signal peptide region
510 691 SMART SM00849 Lactamase_B_5a
510 691 InterPro IPR001279 Metallo-beta-lactamase
442 452 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
257 276 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
383 393 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
72 224 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
261 283 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
329 348 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
424 441 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
23 40 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
283 300 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
394 418 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
277 282 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
306 324 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
394 416 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
453 471 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
225 245 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
360 382 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
472 756 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
49 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
507 680 Pfam PF00753 Metallo-beta-lactamase superfamily
507 680 InterPro IPR001279 Metallo-beta-lactamase
328 345 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
360 382 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
419 423 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
50 71 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
246 256 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
349 359 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
498 737 Gene3D G3DSA:3.60.15.10 -
498 737 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
203 467 Pfam PF03772 Competence protein
203 467 InterPro IPR004477 ComEC/Rec2-related protein
6 749 PANTHER PTHR30619 DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2
497 743 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase
497 743 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
325 328 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
41 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMB1
AlphaFold — — full sequence — Viewing
ColabFold KP13_04196
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
65 0.999
35 0.956
69 0.392

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.29 0.819
2 13.84 0.701
3 8.74 0.468
4 5.84 0.285
5 4.8 0.213