Protein profile

KP13_04197

Integration host factor subunit beta

Genome: KpKP13

Gene: AHE45428.1 ihfB Structure source: AlphaFold + ColabFold UniProt A0A0H3GQN5
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Amino acids 102
Annotations 7
Features 22
PDB binders 0
Druggability 0.367

Overview

Basic information about this protein and its source genome.

Accession
KP13_04197
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45428.1 ihfB
Status
annotated
Amino acids
102
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin. GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
56.701
DEG E-value
4.01e-33
Localization
Cytoplasmic
ColabFold pLDDT
94.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.367
Structure A0A0H3GQN5
Pocket Pocket 5
P2Rank 0.002
Structure A0A0H3GQN5
Pocket Pocket 1
ColabFold model
FPocket 0.588 · Pocket 5
P2Rank 0.002 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 225 / 4744 genomes with a hit
Normalized 0.047

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.
  • GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
8 101 Gene3D G3DSA:4.10.520.10 -
8 101 InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
8 98 SMART SM00411 bhlneu
8 98 InterPro IPR000119 Histone-like DNA-binding protein
8 101 Hamap MF_00381 Integration host factor subunit beta [ihfB].
8 101 InterPro IPR005685 Integration host factor, beta subunit
8 101 FunFam G3DSA:4.10.520.10:FF:000003 Integration host factor subunit beta
8 101 NCBIfam TIGR00988 integration host factor subunit beta
8 97 PANTHER PTHR33175 DNA-BINDING PROTEIN HU
8 97 InterPro IPR000119 Histone-like DNA-binding protein
8 96 CDD cd13836 IHF_B
8 98 SUPERFAMILY SSF47729 IHF-like DNA-binding proteins
8 98 InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
8 98 Pfam PF00216 Bacterial DNA-binding protein
54 73 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature.
54 73 InterPro IPR020816 Histone-like DNA-binding protein, conserved site
66 79 PRINTS PR01727 Prokaryotic integration host factor signature
66 79 InterPro IPR000119 Histone-like DNA-binding protein
48 63 PRINTS PR01727 Prokaryotic integration host factor signature
48 63 InterPro IPR000119 Histone-like DNA-binding protein
82 96 PRINTS PR01727 Prokaryotic integration host factor signature
82 96 InterPro IPR000119 Histone-like DNA-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQN5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04197
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.367