Protein profile

KP13_04204

putative formate transporter 1

Genome: KpKP13

Gene: focA AHE45435.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GL09

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Amino acids 285

Annotations 7

Features 34

PDB binders 2

Druggability 0.876

Overview

Basic information about this protein and its source genome.

Accession: KP13_04204
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: focA AHE45435.1
Status: annotated
Amino acids: 285
Structure source: AlphaFold + ColabFold

GO:0015499 Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015724 The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 53.232
DEG E-value: 3.76e-104
Localization: CytoplasmicMembrane
ColabFold pLDDT: 92.6

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.876

Structure A0A0H3GL09

Pocket Pocket 7

P2Rank 0.742

Structure A0A0H3GL09

Pocket Pocket 1

ColabFold model

FPocket 0.862 · Pocket 6

P2Rank 0.585 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 144 / 4744 genomes with a hit

Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

GO:0015499 Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0015724 The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0042802 Binding to an identical protein or proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records

Show feature table

Start	End	DB	Term	Name
75	101	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
26	280	NCBIfam	TIGR00790	formate/nitrite family transporter
26	280	InterPro	IPR000292	Formate/nitrite transporter
77	99	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
278	285	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
184	194	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
56	74	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	268	Gene3D	G3DSA:1.20.1080.10	Glycerol uptake facilitator protein.
1	268	InterPro	IPR023271	Aquaporin-like
35	55	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	282	PANTHER	PTHR30520	FORMATE TRANSPORTER-RELATED
1	282	InterPro	IPR000292	Formate/nitrite transporter
119	141	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
16	276	Pfam	PF01226	Formate/nitrite transporter
16	276	InterPro	IPR000292	Formate/nitrite transporter
14	279	NCBIfam	TIGR04060	formate transporter FocA
14	279	InterPro	IPR023999	Formate transporter FocA
164	183	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
135	163	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
83	92	ProSitePatterns	PS01005	Formate and nitrite transporters signature 1.
83	92	InterPro	IPR024002	Formate/nitrite transporter, conserved site
195	223	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
161	183	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
168	178	ProSitePatterns	PS01006	Formate and nitrite transporters signature 2.
168	178	InterPro	IPR024002	Formate/nitrite transporter, conserved site
255	277	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
113	134	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
35	57	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
256	278	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
102	112	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	268	FunFam	G3DSA:1.20.1080.10:FF:000006	Formate transporter FocA
1	34	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
224	254	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
195	217	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GL09	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04204	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
7				0.876
17				0.252

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	9.85	0.529
2	5.97	0.293
3	1.63	0.026
4	1.55	0.023
5	1.46	0.02

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.862
16				0.342

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	8.64	0.462
2	5.87	0.287
3	1.78	0.033
4	1.31	0.014
5	1.21	0.011

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
HV6	7E27	O77389	312.2 Da LogP 3.22 TPSA 66.8	✓ Ro5	✓ Clean	`COc1ccc(c(c1)O)C(=O)/C=C(/C(C(F)(F)F)(F)F)\O`
R7M	6VQR	O77389	312.2 Da LogP 2.55 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@](CC2=O)(C(C(F)(F)F)(F)F)O`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC305070	1.000	312.2 Da LogP 2.55 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@@](O)(C(F)(F)C(F)(F)F)CC2=O`
ZINC305075	1.000	312.2 Da LogP 2.55 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@](O)(C(F)(F)C(F)(F)F)CC2=O`
ZINC2269662	0.844	412.2 Da LogP 3.82 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@@](O)(C(F)(F)C(F)(F)C(F)(F)C(F…`
ZINC2269663	0.844	412.2 Da LogP 3.82 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@](O)(C(F)(F)C(F)(F)C(F)(F)C(F)…`
ZINC510164	0.818	312.2 Da LogP 2.55 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)C(=O)C[C@@](O)(C(F)(F)C(F)(F)F)O2`
ZINC510165	0.818	312.2 Da LogP 2.55 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)C(=O)C[C@](O)(C(F)(F)C(F)(F)F)O2`
ZINC185374	0.814	262.2 Da LogP 1.91 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@@](O)(C(F)(F)F)CC2=O`
ZINC185379	0.814	262.2 Da LogP 1.91 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@](O)(C(F)(F)F)CC2=O`
ZINC185396	0.745	294.2 Da LogP 2.25 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@@](O)(C(F)(F)C(F)F)CC2=O`
ZINC185400	0.745	294.2 Da LogP 2.25 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@](O)(C(F)(F)C(F)F)CC2=O`
ZINC352495	0.660	262.2 Da LogP 1.91 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)C(=O)C[C@@](O)(C(F)(F)F)O2`
ZINC352496	0.660	262.2 Da LogP 1.91 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)C(=O)C[C@](O)(C(F)(F)F)O2`
ZINC100477125	0.659	261.2 Da LogP 1.99 TPSA 72.5	✓ Ro5	✓ Clean	`COc1ccc(C(=O)/C=C(\N)C(F)(F)F)c(O)c1`
ZINC62765	0.652	244.2 Da LogP 1.61 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@@](O)(C(F)F)CC2=O`
ZINC62766	0.652	244.2 Da LogP 1.61 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)O[C@](O)(C(F)F)CC2=O`
ZINC2564985	0.634	206.2 Da LogP 2.55 TPSA 46.5	✓ Ro5	Alert	`COc1ccc(C(=O)C=C(C)C)c(O)c1`
ZINC306607	0.622	282.2 Da LogP 2.54 TPSA 46.5	✓ Ro5	✓ Clean	`O=C1C[C@@](O)(C(F)(F)C(F)(F)F)Oc2ccccc21`
ZINC306608	0.622	282.2 Da LogP 2.54 TPSA 46.5	✓ Ro5	✓ Clean	`O=C1C[C@](O)(C(F)(F)C(F)(F)F)Oc2ccccc21`
ZINC510413	0.608	294.2 Da LogP 2.25 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)C(=O)C[C@@](O)(C(F)(F)C(F)F)O2`
ZINC510414	0.608	294.2 Da LogP 2.25 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)C(=O)C[C@](O)(C(F)(F)C(F)F)O2`
ZINC2237688	0.604	296.2 Da LogP 2.85 TPSA 46.5	✓ Ro5	✓ Clean	`Cc1ccc2c(c1)C(=O)C[C@@](O)(C(F)(F)C(F)(F)F)O2`
ZINC2237689	0.604	296.2 Da LogP 2.85 TPSA 46.5	✓ Ro5	✓ Clean	`Cc1ccc2c(c1)C(=O)C[C@](O)(C(F)(F)C(F)(F)F)O2`
ZINC163342	0.600	206.2 Da LogP 2.44 TPSA 35.5	✓ Ro5	✓ Clean	`COc1ccc2c(c1)OC(C)(C)CC2=O`
ZINC6621609	0.587	310.6 Da LogP 2.80 TPSA 72.5	✓ Ro5	✓ Clean	`COc1ccc(C(=O)/C=C(\N)C(Cl)(Cl)Cl)c(O)c1`
ZINC307341	0.571	316.6 Da LogP 3.19 TPSA 46.5	✓ Ro5	✓ Clean	`O=C1C[C@@](O)(C(F)(F)C(F)(F)F)Oc2ccc(Cl)cc21`
ZINC307342	0.571	316.6 Da LogP 3.19 TPSA 46.5	✓ Ro5	✓ Clean	`O=C1C[C@](O)(C(F)(F)C(F)(F)F)Oc2ccc(Cl)cc21`
ZINC155181	0.564	274.3 Da LogP 2.35 TPSA 76.0	✓ Ro5	✓ Clean	`COc1ccc(C(=O)c2ccc(OC)cc2O)c(O)c1`
ZINC164955549	0.563	232.3 Da LogP 2.97 TPSA 35.5	✓ Ro5	✓ Clean	`COc1ccc2c(c1)OC1(CCCC1)CC2=O`
ZINC536952832	0.560	282.3 Da LogP 3.61 TPSA 35.5	✓ Ro5	✓ Clean	`COc1ccc2c(c1)OC1(CCC(F)(F)CC1)CC2=O`
ZINC34463037	0.551	246.3 Da LogP 3.36 TPSA 35.5	✓ Ro5	✓ Clean	`COc1ccc2c(c1)OC1(CCCCC1)CC2=O`
ZINC101388655	0.543	346.2 Da LogP 4.15 TPSA 46.5	✓ Ro5	✓ Clean	`COc1ccc(C(=O)/C=C(\O)C(F)(F)C(F)(F)C(F)(F)F)cc1`
ZINC234879321	0.533	288.6 Da LogP 3.73 TPSA 26.3	✓ Ro5	✓ Clean	`COc1ccc(C(=O)C(F)(F)C(F)(F)F)c(Cl)c1`
ZINC17381066	0.532	254.3 Da LogP 3.30 TPSA 46.5	✓ Ro5	✓ Clean	`COc1ccc(C(=O)/C=C\c2ccccc2)c(O)c1`
ZINC4104687	0.532	254.3 Da LogP 3.30 TPSA 46.5	✓ Ro5	✓ Clean	`COc1ccc(C(=O)/C=C/c2ccccc2)c(O)c1`
ZINC96341526	0.531	298.3 Da LogP 3.00 TPSA 83.8	✓ Ro5	✓ Clean	`COc1ccc(C(=O)/C=C/c2ccc(C(=O)O)cc2)c(O)c1`
ZINC11849209	0.529	247.3 Da LogP 1.78 TPSA 47.6	✓ Ro5	✓ Clean	`COc1ccc2c(c1)OC1(CCNCC1)CC2=O`
ZINC136138	0.523	228.2 Da LogP 2.63 TPSA 46.5	✓ Ro5	✓ Clean	`COc1ccc(C(=O)c2ccccc2)c(O)c1`
ZINC17005691	0.522	218.3 Da LogP 2.72 TPSA 46.5	✓ Ro5	✓ Clean	`C/C=C\C=C/C(=O)c1ccc(OC)cc1O`
ZINC17005695	0.522	218.3 Da LogP 2.72 TPSA 46.5	✓ Ro5	✓ Clean	`C/C=C\C=C\C(=O)c1ccc(OC)cc1O`
ZINC17005698	0.522	218.3 Da LogP 2.72 TPSA 46.5	✓ Ro5	✓ Clean	`C/C=C/C=C\C(=O)c1ccc(OC)cc1O`
ZINC1729936	0.522	218.3 Da LogP 2.72 TPSA 46.5	✓ Ro5	✓ Clean	`C/C=C/C=C/C(=O)c1ccc(OC)cc1O`
ZINC26461571	0.522	221.3 Da LogP 1.66 TPSA 49.8	✓ Ro5	✓ Clean	`COc1ccc(C(=O)/C=C/N(C)C)c(O)c1`
ZINC4252588	0.522	284.3 Da LogP 3.31 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc(/C=C/C(=O)c2ccc(OC)cc2O)cc1`
ZINC4532316	0.522	284.3 Da LogP 3.31 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc(/C=C\C(=O)c2ccc(OC)cc2O)cc1`
ZINC4551810	0.521	261.2 Da LogP 1.99 TPSA 72.5	✓ Ro5	✓ Clean	`COc1ccc(O)c(C(=O)/C=C(\N)C(F)(F)F)c1`
ZINC2317084	0.520	382.2 Da LogP 3.81 TPSA 46.5	✓ Ro5	✓ Clean	`O=C1C[C@@](O)(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)Oc2…`
ZINC2317085	0.520	382.2 Da LogP 3.81 TPSA 46.5	✓ Ro5	✓ Clean	`O=C1C[C@](O)(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)Oc2c…`
ZINC438317	0.520	244.2 Da LogP 1.61 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)C(=O)C[C@@](O)(C(F)F)O2`
ZINC438318	0.520	244.2 Da LogP 1.61 TPSA 55.8	✓ Ro5	✓ Clean	`COc1ccc2c(c1)C(=O)C[C@](O)(C(F)F)O2`
ZINC554662	0.520	310.2 Da LogP 3.15 TPSA 46.5	✓ Ro5	✓ Clean	`Cc1cc(C)c2c(c1)O[C@](O)(C(F)(F)C(F)(F)F)CC2=O`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.