Protein profile

KP13_04207

putative MFS-type transporter

Genome: KpKP13

Gene: AHE45438.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQM8

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Amino acids 382

Annotations 3

Features 58

PDB binders 0

Druggability 0.582

Overview

Basic information about this protein and its source genome.

Accession: KP13_04207
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE45438.1
Status: annotated
Amino acids: 382
Structure source: AlphaFold + ColabFold

GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 89.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.582

Structure A0A0H3GQM8

Pocket Pocket 11

P2Rank 0.964

Structure A0A0H3GQM8

Pocket Pocket 1

ColabFold model

FPocket 0.999 · Pocket 1

P2Rank 0.967 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 99 / 4744 genomes with a hit

Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

58 records

Show feature table

Start	End	DB	Term	Name
43	65	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	368	CDD	cd17477	MFS_YcaD_like
21	368	InterPro	IPR047200	MSF-type transporter YcaD-like
151	161	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
8	191	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
8	191	InterPro	IPR036259	MFS transporter superfamily
162	181	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
11	22	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
132	150	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	376	ProSiteProfiles	PS50850	Major facilitator superfamily (MFS) profile.
7	376	InterPro	IPR020846	Major facilitator superfamily domain
12	34	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
76	98	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
131	150	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	370	SUPERFAMILY	SSF103473	MFS general substrate transporter
7	370	InterPro	IPR036259	MFS transporter superfamily
102	120	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	382	Hamap	MF_01149	Uncharacterized MFS-type transporter YcaD [ycaD].
1	382	InterPro	IPR023745	MSF-type transporter YcaD
121	131	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
210	370	Pfam	PF07690	Major Facilitator Superfamily
210	370	InterPro	IPR011701	Major facilitator superfamily
11	194	Pfam	PF07690	Major Facilitator Superfamily
11	194	InterPro	IPR011701	Major facilitator superfamily
289	311	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
320	342	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
352	369	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
97	101	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
102	124	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
292	311	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	381	PANTHER	PTHR23521	TRANSPORTER MFS SUPERFAMILY
160	182	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
265	283	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	181	FunFam	G3DSA:1.20.1250.20:FF:000066	Uncharacterized MFS-type transporter YcaD
200	378	FunFam	G3DSA:1.20.1250.20:FF:000041	Uncharacterized MFS-type transporter YcaD
224	234	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
351	369	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
266	288	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
208	375	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
208	375	InterPro	IPR036259	MFS transporter superfamily
205	227	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
237	259	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
74	96	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
312	322	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
323	345	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
346	350	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
28	42	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
370	382	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
235	253	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	10	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
284	288	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
182	201	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
202	223	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
23	27	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
44	63	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	27	Phobius	SIGNAL_PEPTIDE	Signal peptide region
254	264	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
66	73	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GQM8	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04207	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
11				0.582
21				0.033
16				0.001
19				0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	48.25	0.964
2	7.65	0.339
3	2.96	0.077
4	2.72	0.066

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.999
29				0.212
28				0.068
15				0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	49.9	0.967
2	3.08	0.082
3	2.1	0.04
4	1.46	0.016
5	1.42	0.015