Protein profile

KP13_04214

DNA translocase ftsK

Genome: KpKP13

Gene: ftsK AHE45445.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUY9
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Amino acids 1424
Annotations 7
Features 62
PDB binders 1
Druggability 0.849

Overview

Basic information about this protein and its source genome.

Accession
KP13_04214
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ftsK AHE45445.1
Status
annotated
Amino acids
1424
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0071236 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.401
Human E-value
9.04e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
96.686
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
63.59

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.849
Structure A0A0H3GUY9
Pocket Pocket 63
P2Rank 0.141
Structure A0A0H3GUY9
Pocket Pocket 1
ColabFold model
FPocket 0.696 · Pocket 65
P2Rank 0.181 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 78 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
  • GO:0071236 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
  • GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

Sequence Features

Domain/signature hits from InterPro and related databases.

62 records
Show feature table
Start End DB Term Name
873 887 MobiDBLite mobidb-lite consensus disorder prediction
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
45 74 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
623 637 MobiDBLite mobidb-lite consensus disorder prediction
165 187 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
110 131 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1017 1329 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
1017 1329 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1069 1282 ProSiteProfiles PS50901 FtsK domain profile.
1069 1282 InterPro IPR002543 FtsK domain
159 164 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
213 228 MobiDBLite mobidb-lite consensus disorder prediction
351 588 MobiDBLite mobidb-lite consensus disorder prediction
1 1423 PANTHER PTHR22683 SPORULATION PROTEIN RELATED
1357 1422 SMART SM00843 FtsK_gamma_2
1357 1422 InterPro IPR018541 FtsK gamma domain
212 233 MobiDBLite mobidb-lite consensus disorder prediction
1359 1419 Pfam PF09397 Ftsk gamma domain
1359 1419 InterPro IPR018541 FtsK gamma domain
796 810 MobiDBLite mobidb-lite consensus disorder prediction
935 1039 Gene3D G3DSA:3.30.980.40 -
1040 1342 FunFam G3DSA:3.40.50.300:FF:000209 Cell division protein FtsK
20 191 Pfam PF13491 4TM region of DNA translocase FtsK/SpoIIIE
20 191 InterPro IPR025199 DNA translocase FtsK, 4TM region
935 1035 Pfam PF17854 FtsK alpha domain
935 1035 InterPro IPR041027 FtsK alpha domain
132 136 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
657 935 MobiDBLite mobidb-lite consensus disorder prediction
137 158 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
620 642 MobiDBLite mobidb-lite consensus disorder prediction
1040 1342 Gene3D G3DSA:3.40.50.300 -
1040 1342 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1357 1421 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
1357 1421 InterPro IPR036390 Winged helix DNA-binding domain superfamily
811 911 CDD cd22541 SP5_N
662 685 MobiDBLite mobidb-lite consensus disorder prediction
110 132 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
99 109 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
725 743 MobiDBLite mobidb-lite consensus disorder prediction
845 870 MobiDBLite mobidb-lite consensus disorder prediction
137 158 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1043 1256 Pfam PF01580 FtsK/SpoIIIE family
1043 1256 InterPro IPR002543 FtsK domain
22 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
554 583 MobiDBLite mobidb-lite consensus disorder prediction
1355 1418 FunFam G3DSA:1.10.10.10:FF:000268 DNA translocase FtsK
1354 1418 Gene3D G3DSA:1.10.10.10 -
1354 1418 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
935 1039 FunFam G3DSA:3.30.980.40:FF:000001 DNA translocase FtsK
165 184 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
75 97 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1081 1273 CDD cd01127 TrwB_TraG_TraD_VirD4
185 1424 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
75 98 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
488 504 PRINTS PR01217 Proline rich extensin signature
444 456 PRINTS PR01217 Proline rich extensin signature
531 556 PRINTS PR01217 Proline rich extensin signature
415 431 PRINTS PR01217 Proline rich extensin signature
506 523 PRINTS PR01217 Proline rich extensin signature
459 480 PRINTS PR01217 Proline rich extensin signature
397 409 PRINTS PR01217 Proline rich extensin signature

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUY9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04214
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
63 0.849

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.54 0.071
2 2.17 0.051
3 2.08 0.047
4 1.9 0.038
5 1.86 0.036

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AGS
2IUT
Q9I0M3 523.2 Da LogP -1.51 TPSA 262.1 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.