Protein profile

KP13_04227

hypothetical protein

Genome: KpKP13

Gene: AHE45458.1 Structure source: AlphaFold + ColabFold UniProt A0A1Y0Q2K5
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Amino acids 552
Annotations 3
Features 11
PDB binders 0
Druggability 0.565

Overview

Basic information about this protein and its source genome.

Accession
KP13_04227
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45458.1
Status
annotated
Amino acids
552
Structure source
AlphaFold + ColabFold
GO
GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
84.42
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
84.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.565
Structure A0A1Y0Q2K5
Pocket Pocket 44
P2Rank 0.192
Structure A0A1Y0Q2K5
Pocket Pocket 1
ColabFold model
FPocket 0.301 · Pocket 38
P2Rank 0.542 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
  • GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 375 Pfam PF11398 Protein of unknown function (DUF2813)
1 375 InterPro IPR022602 Protein of unknown function DUF2813
1 347 Gene3D G3DSA:3.40.50.300 -
1 347 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 536 PANTHER PTHR32182 DNA REPLICATION AND REPAIR PROTEIN RECF
376 472 CDD cd01026 TOPRIM_OLD
376 472 InterPro IPR034139 OLD protein-like, TOPRIM domain
376 440 Pfam PF20469 Overcoming lysogenization defect protein-like, TOPRIM domain
376 440 InterPro IPR034139 OLD protein-like, TOPRIM domain
1 339 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
1 339 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1Y0Q2K5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04227
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.066
49 0.01
2 0.0
48 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.1 0.192
2 2.94 0.076
3 2.72 0.066
4 2.6 0.061
5 1.62 0.022