Protein profile

KP13_04248

putative transcriptional regulator

Genome: KpKP13

Gene: AHE45480.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQV0
Export view
Amino acids 238
Annotations 7
Features 25
PDB binders 2
Druggability 0.251

Overview

Basic information about this protein and its source genome.

Accession
KP13_04248
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45480.1
Status
annotated
Amino acids
238
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0000156 Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
44.681
DEG E-value
1.1e-66
Localization
Cytoplasmic
ColabFold pLDDT
86.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.251
Structure A0A0H3GQV0
Pocket Pocket 3
P2Rank 0.213
Structure A0A0H3GQV0
Pocket Pocket 1
ColabFold model
FPocket 0.14 · Pocket 5
P2Rank 0.168 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0000156 Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
1 82 FunFam G3DSA:3.40.50.2300:FF:000001 DNA-binding response regulator PhoB
3 127 SUPERFAMILY SSF52172 CheY-like
3 127 InterPro IPR011006 CheY-like superfamily
153 229 Pfam PF00486 Transcriptional regulatory protein, C terminal
153 229 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
3 114 SMART SM00448 REC_2
3 114 InterPro IPR001789 Signal transduction response regulator, receiver domain
129 231 FunFam G3DSA:1.10.10.10:FF:000018 DNA-binding response regulator ResD
83 120 Gene3D G3DSA:6.10.250.690 -
4 118 ProSiteProfiles PS50110 Response regulatory domain profile.
4 118 InterPro IPR001789 Signal transduction response regulator, receiver domain
131 230 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
131 230 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
126 235 Gene3D G3DSA:1.10.10.10 -
126 235 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
1 82 Gene3D G3DSA:3.40.50.2300 -
153 229 SMART SM00862 Trans_reg_C_3
4 234 PANTHER PTHR48111 REGULATOR OF RPOS
4 234 InterPro IPR039420 Transcriptional regulatory protein WalR-like
5 114 Pfam PF00072 Response regulator receiver domain
5 114 InterPro IPR001789 Signal transduction response regulator, receiver domain
140 229 CDD cd00383 trans_reg_C
140 229 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
132 231 ProSiteProfiles PS51755 OmpR/PhoB-type DNA-binding domain profile.
132 231 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQV0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04248
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.251

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.61 0.135
2 1.18 0.01

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
BEF
6EB7
A0A0H2UQ68 66.0 Da LogP 0.88 TPSA 0.0 ✓ Ro5 ✓ Clean [Be-](F)(F)F
PHS
1NXP
A0A0H2UQ68 82.0 Da LogP -0.64 TPSA 57.5 ✓ Ro5 ✓ Clean OP(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.