Protein profile

KP13_04262

putative transport protein

Genome: KpKP13

Gene: AHE45492.1 Structure source: AlphaFold + ColabFold UniProt A6T6U3

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Amino acids 561

Annotations 2

Features 58

PDB binders 0

Druggability 0.911

Overview

Basic information about this protein and its source genome.

Accession: KP13_04262
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE45492.1
Status: annotated
Amino acids: 561
Structure source: AlphaFold + ColabFold

GO:0006813 The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008324 Enables the transfer of cation from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 85.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.911

Structure A6T6U3

Pocket Pocket 2

P2Rank 0.594

Structure A6T6U3

Pocket Pocket 1

ColabFold model

FPocket 0.72 · Pocket 40

P2Rank 0.751 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 106 / 4744 genomes with a hit

Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0006813 The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0008324 Enables the transfer of cation from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

58 records

Show feature table

Start	End	DB	Term	Name
224	286	FunFam	G3DSA:3.30.70.1450:FF:000003	Putative transport protein YbjL
499	531	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
161	181	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
56	60	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
93	115	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
223	286	Gene3D	G3DSA:3.30.70.1450	-
223	286	InterPro	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily
535	557	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
406	426	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
465	475	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
37	55	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
476	498	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	557	Hamap	MF_01015	Putative transport protein YbjL [ybjL].
1	557	InterPro	IPR023017	Transport protein YbjL, putative
427	446	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21	559	PANTHER	PTHR30445	UNCHARACTERIZED
12	30	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
558	561	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
291	374	SUPERFAMILY	SSF116726	TrkA C-terminal domain-like
291	374	InterPro	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily
380	400	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
31	36	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
532	557	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
305	371	Pfam	PF02080	TrkA-C domain
305	371	InterPro	IPR006037	Regulator of K+ conductance, C-terminal
227	282	Pfam	PF02080	TrkA-C domain
227	282	InterPro	IPR006037	Regulator of K+ conductance, C-terminal
1	11	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
202	288	ProSiteProfiles	PS51202	RCK C-terminal domain profile.
202	288	InterPro	IPR006037	Regulator of K+ conductance, C-terminal
115	160	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
383	402	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
92	114	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
385	554	Pfam	PF06826	Predicted Permease Membrane Region
385	554	InterPro	IPR006512	YidE/YbjL duplication
17	181	Pfam	PF06826	Predicted Permease Membrane Region
17	181	InterPro	IPR006512	YidE/YbjL duplication
227	282	SUPERFAMILY	SSF116726	TrkA C-terminal domain-like
227	282	InterPro	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily
61	85	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
476	498	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
449	471	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
292	373	ProSiteProfiles	PS51202	RCK C-terminal domain profile.
292	373	InterPro	IPR006037	Regulator of K+ conductance, C-terminal
447	464	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	168	NCBIfam	TIGR01625	AspT/YidE/YbjL antiporter duplication domain
21	168	InterPro	IPR006512	YidE/YbjL duplication
391	541	NCBIfam	TIGR01625	AspT/YidE/YbjL antiporter duplication domain
391	541	InterPro	IPR006512	YidE/YbjL duplication
86	91	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
401	405	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
406	428	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
304	373	Gene3D	G3DSA:3.30.70.1450	-
304	373	InterPro	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily
64	86	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
182	379	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
159	178	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A6T6U3	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04262	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.911
34				0.814
23				0.352
26				0.202

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	8.27	0.441
2	7.62	0.402
3	6.06	0.3
4	4.63	0.201
5	4.07	0.163

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
40				0.72
38				0.26
8				0.251

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	9.54	0.513
2	9.16	0.49
3	8.55	0.457
4	5.75	0.28
5	4.16	0.169