Protein profile

KP13_04270

Putative undecaprenyl-diphosphatase

Genome: KpKP13

Gene: AHE45500.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQN7
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Amino acids 197
Annotations 3
Features 25
PDB binders 0
Druggability 0.975

Overview

Basic information about this protein and its source genome.

Accession
KP13_04270
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45500.1
Status
annotated
Amino acids
197
Structure source
AlphaFold + ColabFold
EC
3.6.1.27
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050380 Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.244
DEG E-value
4.17e-65
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.975
Structure A0A0H3GQN7
Pocket Pocket 7
P2Rank 0.184
Structure A0A0H3GQN7
Pocket Pocket 1
ColabFold model
FPocket 0.915 · Pocket 3
P2Rank 0.158 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 98 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0050380 Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
144 148 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 163 CDD cd03385 PAP2_BcrC_like
24 163 InterPro IPR033879 Undecaprenyl-diphosphatase
171 197 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
99 118 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
48 58 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
149 171 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
57 164 SMART SM00014 acid_phosph_2
57 164 InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
125 143 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
80 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 48 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 160 PANTHER PTHR14969 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE
57 166 Pfam PF01569 PAP2 superfamily
57 166 InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
120 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
149 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
119 124 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
55 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
59 79 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
87 181 Gene3D G3DSA:1.20.144.10 Phosphatidic acid phosphatase type 2/haloperoxidase
22 47 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 195 SUPERFAMILY SSF48317 Acid phosphatase/Vanadium-dependent haloperoxidase
3 195 InterPro IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQN7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04270
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.975
6 0.606
3 0.355
5 0.306

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.35 0.119
2 2.43 0.066
3 1.84 0.035
4 1.42 0.018