Protein profile

KP13_04278

Raffinose permease

Genome: KpKP13

Gene: AHE45512.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUL7
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Amino acids 413
Annotations 6
Features 62
PDB binders 0
Druggability 0.777

Overview

Basic information about this protein and its source genome.

Accession
KP13_04278
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45512.1
Status
annotated
Amino acids
413
Structure source
AlphaFold + ColabFold
GO
GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0030395 Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. GO:0015528 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.426
DEG E-value
5.439999999999999e-91
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.777
Structure A0A0H3GUL7
Pocket Pocket 8
P2Rank 0.946
Structure A0A0H3GUL7
Pocket Pocket 1
ColabFold model
FPocket 0.909 · Pocket 15
P2Rank 0.968 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0030395 Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.
  • GO:0015528 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in).

Sequence Features

Domain/signature hits from InterPro and related databases.

62 records
Show feature table
Start End DB Term Name
230 252 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
64 74 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
34 44 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
96 100 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
45 63 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
253 275 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
285 307 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
162 166 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 397 SUPERFAMILY SSF103473 MFS general substrate transporter
5 397 InterPro IPR036259 MFS transporter superfamily
122 141 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
253 276 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
75 95 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
371 392 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 193 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
4 193 InterPro IPR036259 MFS transporter superfamily
5 397 Pfam PF01306 LacY proton/sugar symporter
5 397 InterPro IPR000576 LacY/RafB permease family
189 208 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
277 282 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 400 PANTHER PTHR23522 BLL5896 PROTEIN
44 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
209 229 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
101 121 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
307 330 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
167 188 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
283 301 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
166 188 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
331 341 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
213 232 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
368 390 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
142 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 124 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
393 413 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
75 97 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
302 306 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
342 364 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
342 365 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
366 370 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 392 NCBIfam TIGR00882 oligosaccharide MFS transporter
6 392 InterPro IPR000576 LacY/RafB permease family
199 402 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
199 402 InterPro IPR036259 MFS transporter superfamily
339 359 PRINTS PR00174 LacY proton/sugar symporter family signature
339 359 InterPro IPR000576 LacY/RafB permease family
102 124 PRINTS PR00174 LacY proton/sugar symporter family signature
102 124 InterPro IPR000576 LacY/RafB permease family
67 96 PRINTS PR00174 LacY proton/sugar symporter family signature
67 96 InterPro IPR000576 LacY/RafB permease family
308 327 PRINTS PR00174 LacY proton/sugar symporter family signature
308 327 InterPro IPR000576 LacY/RafB permease family
253 274 PRINTS PR00174 LacY proton/sugar symporter family signature
253 274 InterPro IPR000576 LacY/RafB permease family
277 303 PRINTS PR00174 LacY proton/sugar symporter family signature
277 303 InterPro IPR000576 LacY/RafB permease family
144 162 PRINTS PR00174 LacY proton/sugar symporter family signature
144 162 InterPro IPR000576 LacY/RafB permease family
207 235 PRINTS PR00174 LacY proton/sugar symporter family signature
207 235 InterPro IPR000576 LacY/RafB permease family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUL7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04278
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.777
28 0.562

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 25.76 0.908
2 4.33 0.18
3 2.68 0.079
4 1.88 0.038
5 1.75 0.032