Protein profile

KP13_04281

Glutathione transport system permease protein gsiD

Genome: KpKP13

Gene: AHE45515.1 gsiD Structure source: AlphaFold + ColabFold UniProt A0A0H3GQC7
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Amino acids 303
Annotations 4
Features 33
PDB binders 0
Druggability 0.667

Overview

Basic information about this protein and its source genome.

Accession
KP13_04281
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45515.1 gsiD
Status
annotated
Amino acids
303
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.652
DEG E-value
8.1e-74
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.667
Structure A0A0H3GQC7
Pocket Pocket 13
P2Rank 0.502
Structure A0A0H3GQC7
Pocket Pocket 1
ColabFold model
FPocket 0.693 · Pocket 16
P2Rank 0.528 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 163 / 4744 genomes with a hit
Normalized 0.034

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
222 247 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
136 158 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
248 266 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
96 284 SUPERFAMILY SSF161098 MetI-like
96 284 InterPro IPR035906 MetI-like superfamily
1 38 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
291 303 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
92 298 Gene3D G3DSA:1.10.3720.10 -
92 298 InterPro IPR035906 MetI-like superfamily
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
130 135 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
159 163 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
101 290 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
101 290 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
164 183 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 298 FunFam G3DSA:1.10.3720.10:FF:000022 Glutathione ABC transporter permease GsiD
62 102 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
103 129 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
267 290 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
225 247 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
184 221 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
136 158 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
119 302 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
119 302 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
107 129 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
30 301 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
101 293 CDD cd06261 TM_PBP2
101 293 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
163 185 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
267 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 75 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
25 75 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQC7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04281
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.667
19 0.457
7 0.346

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.47 0.563
2 3.75 0.144
3 3.74 0.144
4 1.44 0.019
5 0.91 0.004