Protein profile

KP13_04282

Glutathione transport system permease protein gsiC

Genome: KpKP13

Gene: gsiC AHE45516.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQN0
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Amino acids 306
Annotations 3
Features 33
PDB binders 0
Druggability 0.797

Overview

Basic information about this protein and its source genome.

Accession
KP13_04282
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
gsiC AHE45516.1
Status
annotated
Amino acids
306
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.667
DEG E-value
4.04e-76
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.34

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.797
Structure A0A0H3GQN0
Pocket Pocket 21
P2Rank 0.542
Structure A0A0H3GQN0
Pocket Pocket 1
ColabFold model
FPocket 0.998 · Pocket 4
P2Rank 0.422 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 145 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
91 288 SUPERFAMILY SSF161098 MetI-like
91 288 InterPro IPR035906 MetI-like superfamily
300 306 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
192 226 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
101 123 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
173 191 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
227 249 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
278 299 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 8 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
95 292 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
95 292 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
135 157 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
154 172 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
113 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
113 304 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
250 277 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
86 300 Gene3D G3DSA:1.10.3720.10 -
86 300 InterPro IPR035906 MetI-like superfamily
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
278 300 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
134 153 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
123 133 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
172 191 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 306 PANTHER PTHR43163 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
1 76 Pfam PF19300 Binding-prot-dependent transport system membrane comp, N-term
1 76 InterPro IPR045621 ABC transporter type 1, GsiC-like, N-terminal domain
9 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
99 122 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
227 249 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 283 CDD cd06261 TM_PBP2
95 283 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
87 300 FunFam G3DSA:1.10.3720.10:FF:000024 Glutathione ABC transporter permease GsiC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQN0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04282
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
21 0.797
16 0.3
19 0.241

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.07 0.366
2 5.12 0.235
3 4.98 0.226
4 2.7 0.081
5 1.73 0.031