Protein profile

KP13_04303

Transcriptional regulator mntR

Genome: KpKP13

Gene: mntR AHE45536.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQB2
Export view
Amino acids 157
Annotations 6
Features 19
PDB binders 1
Druggability 0.767

Overview

Basic information about this protein and its source genome.

Accession
KP13_04303
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mntR AHE45536.1
Status
annotated
Amino acids
157
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0046914 Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0046983 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
86.452
DEG E-value
1.4499999999999998e-95
Localization
Cytoplasmic
ColabFold pLDDT
90.44

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.767
Structure A0A0H3GQB2
Pocket Pocket 2
P2Rank 0.031
Structure A0A0H3GQB2
Pocket Pocket 1
ColabFold model
FPocket 0.625 · Pocket 7
P2Rank 0.115 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 91 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0046914 Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0046983 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
24 94 FunFam G3DSA:1.10.10.10:FF:000108 Mn-dependent transcriptional regulator MntR
56 154 SMART SM00529 dtx3
56 154 InterPro IPR022689 Iron dependent repressor
24 94 Gene3D G3DSA:1.10.10.10 -
24 94 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
95 155 Gene3D G3DSA:1.10.60.10 Iron dependent repressor, metal binding and dimerisation domain
95 155 InterPro IPR036421 Iron dependent repressor, metal binding and dimerisation domain superfamily
33 153 PANTHER PTHR33238 IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY
95 150 SUPERFAMILY SSF47979 Iron-dependent repressor protein, dimerization domain
95 150 InterPro IPR036421 Iron dependent repressor, metal binding and dimerisation domain superfamily
38 91 Pfam PF01325 Iron dependent repressor, N-terminal DNA binding domain
38 91 InterPro IPR022687 DTXR-type HTH domain
95 155 FunFam G3DSA:1.10.60.10:FF:000002 Mn-dependent transcriptional regulator MntR
95 145 Pfam PF02742 Iron dependent repressor, metal binding and dimerisation domain
95 145 InterPro IPR001367 Iron dependent repressor, metal binding and dimerisation domain
48 118 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
48 118 InterPro IPR036390 Winged helix DNA-binding domain superfamily
34 95 ProSiteProfiles PS50944 DtxR-type HTH domain profile.
34 95 InterPro IPR022687 DTXR-type HTH domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQB2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04303
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.767
8 0.436
11 0.371

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FLC
2EV6
P54512 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.