Protein profile

KP13_04317

C4-type zinc finger protein, DksA/TraR family

Genome: KpKP13

Gene: AHE45551.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQA0
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Amino acids 88
Annotations 2
Features 16
PDB binders 0
Druggability 0.271

Overview

Basic information about this protein and its source genome.

Accession
KP13_04317
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45551.1
Status
annotated
Amino acids
88
Structure source
AlphaFold + ColabFold
GO
GO:0008270 Binding to a zinc ion (Zn). GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
64.773
DEG E-value
3.4599999999999997e-40
Localization
Unknown
ColabFold pLDDT
78.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.271
Structure A0A0H3GQA0
Pocket Pocket 7
P2Rank
Structure A0A0H3GQA0
Pocket No pockets
ColabFold model
FPocket 0.112 · Pocket 6
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 135 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
37 67 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger
37 67 InterPro IPR000962 Zinc finger, DksA/TraR C4-type
6 73 FunFam G3DSA:1.20.120.910:FF:000002 DksA/TraR family C4-type zinc finger protein
39 63 ProSitePatterns PS01102 Prokaryotic dksA C4-type zinc finger.
39 63 InterPro IPR020458 Zinc finger, DksA/TraR C4-type conserved site
10 74 Gene3D G3DSA:1.20.120.910 -
38 73 SUPERFAMILY SSF57716 Glucocorticoid receptor-like (DNA-binding domain)
51 63 PRINTS PR00618 DksA/TraR zinc finger signature
51 63 InterPro IPR020460 Zinc finger, DksA/TraR C4-type, bacteria
39 50 PRINTS PR00618 DksA/TraR zinc finger signature
39 50 InterPro IPR020460 Zinc finger, DksA/TraR C4-type, bacteria
5 76 ProSiteProfiles PS51128 Prokaryotic dksA C4-type zinc finger profiles.
5 76 InterPro IPR000962 Zinc finger, DksA/TraR C4-type
14 67 NCBIfam TIGR02419 phage/conjugal plasmid C-4 type zinc finger protein, TraR family
14 67 InterPro IPR012783 Zinc finger, C4 DksA/TraR-type
1 79 PANTHER PTHR38777 FELS-2 PROPHAGE PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQA0
AlphaFold — — full sequence — Viewing
ColabFold KP13_04317
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.271