Protein profile

KP13_04318

hypothetical protein

Genome: KpKP13

Gene: AHE45552.1 Structure source: AlphaFold + ColabFold UniProt W8V2R8
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Amino acids 122
Annotations 1
Features 12
PDB binders 0
Druggability 0.294

Overview

Basic information about this protein and its source genome.

Accession
KP13_04318
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45552.1
Status
annotated
Amino acids
122
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
69.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.294
Structure W8V2R8
Pocket Pocket 1
P2Rank
Structure W8V2R8
Pocket No pockets
ColabFold model
FPocket 0.062 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 83 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
37 122 PANTHER PTHR34156 OUTER MEMBRANE PROTEIN-RELATED-RELATED
1 58 Phobius SIGNAL_PEPTIDE Signal peptide region
39 122 SUPERFAMILY SSF159871 YdgH-like
39 122 InterPro IPR036275 YdgH-like superfamily
55 58 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
43 54 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
59 122 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 42 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
58 122 Gene3D G3DSA:3.30.1660.10 -
58 122 InterPro IPR025543 Dodecin-like
70 122 Pfam PF07338 YdgH/BhsA/McbA-like domain
70 122 InterPro IPR010854 YdgH/BhsA/McbA-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W8V2R8
AlphaFold — — full sequence — Viewing
ColabFold KP13_04318
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.294