Protein profile

KP13_04328

putative membrane protein

Genome: KpKP13

Gene: AHE45562.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLT5
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Amino acids 331
Annotations 0
Features 17
PDB binders 0
Druggability 0.401

Overview

Basic information about this protein and its source genome.

Accession
KP13_04328
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45562.1
Status
annotated
Amino acids
331
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.23

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.401
Structure A0A0H3GLT5
Pocket Pocket 6
P2Rank
Structure A0A0H3GLT5
Pocket No pockets
ColabFold model
FPocket 0.253 · Pocket 12
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 103 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
42 76 Gene3D G3DSA:2.40.50.100 -
147 174 Coils Coil Coil
180 200 Coils Coil Coil
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
16 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
77 100 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
106 173 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
20 331 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
218 327 Gene3D G3DSA:2.40.30.170 -
41 98 SUPERFAMILY SSF111369 HlyD-like secretion proteins
25 326 PANTHER PTHR32347 EFFLUX SYSTEM COMPONENT YKNX-RELATED
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
35 318 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
35 318 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
177 322 SUPERFAMILY SSF111369 HlyD-like secretion proteins
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLT5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04328
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.401
1 0.254