Protein profile

KP13_04335

Endonuclease/exonuclease/phosphatase

Genome: KpKP13

Gene: AHE45568.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLT2
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Amino acids 242
Annotations 1
Features 8
PDB binders 0
Druggability 0.335

Overview

Basic information about this protein and its source genome.

Accession
KP13_04335
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45568.1
Status
annotated
Amino acids
242
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.471
DEG E-value
3.14e-152
Localization
Cytoplasmic
ColabFold pLDDT
86.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.335
Structure A0A0H3GLT2
Pocket Pocket 11
P2Rank 0.475
Structure A0A0H3GLT2
Pocket Pocket 1
ColabFold model
FPocket 0.787 · Pocket 1
P2Rank 0.416 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 79 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
22 233 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family
22 233 InterPro IPR005135 Endonuclease/exonuclease/phosphatase
21 168 PANTHER PTHR14859 CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR
1 242 FunFam G3DSA:3.60.10.10:FF:000020 Endonuclease/exonuclease/phosphatase family protein
2 240 SUPERFAMILY SSF56219 DNase I-like
2 240 InterPro IPR036691 Endonuclease/exonuclease/phosphatase superfamily
1 242 Gene3D G3DSA:3.60.10.10 Endonuclease/exonuclease/phosphatase
1 242 InterPro IPR036691 Endonuclease/exonuclease/phosphatase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLT2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04335
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.335

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.64 0.337
2 1.36 0.016