Protein profile

KP13_04336

Putative cardiolipin synthase

Genome: KpKP13

Gene: AHE45569.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ81
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Amino acids 414
Annotations 5
Features 22
PDB binders 0
Druggability 0.947

Overview

Basic information about this protein and its source genome.

Accession
KP13_04336
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45569.1
Status
annotated
Amino acids
414
Structure source
AlphaFold + ColabFold
EC
2.7.8.-
GO
GO:0032049 The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008808 Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.947
Structure A0A0H3GQ81
Pocket Pocket 17
P2Rank 0.866
Structure A0A0H3GQ81
Pocket Pocket 1
ColabFold model
FPocket 0.989 · Pocket 35
P2Rank 0.828 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0032049 The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0008808 Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
7 370 PANTHER PTHR21248 CARDIOLIPIN SYNTHASE
202 340 FunFam G3DSA:3.30.870.10:FF:000015 Cardiolipin synthase B
3 195 Gene3D G3DSA:3.30.870.10 Endonuclease Chain A
108 135 SMART SM00155 pld_4
108 135 InterPro IPR001736 Phospholipase D/Transphosphatidylase
286 313 SMART SM00155 pld_4
286 313 InterPro IPR001736 Phospholipase D/Transphosphatidylase
16 167 CDD cd09110 PLDc_CLS_1
4 173 SUPERFAMILY SSF56024 Phospholipase D/nuclease
3 194 FunFam G3DSA:3.30.870.10:FF:000016 Cardiolipin synthase B
26 154 Pfam PF13091 PLD-like domain
26 154 InterPro IPR025202 Phospholipase D-like domain
215 338 Pfam PF13091 PLD-like domain
215 338 InterPro IPR025202 Phospholipase D-like domain
198 360 CDD cd09159 PLDc_ybhO_like_2
186 359 SUPERFAMILY SSF56024 Phospholipase D/nuclease
2 384 Hamap MF_01917 Cardiolipin synthase B [clsB].
2 384 InterPro IPR030872 Cardiolipin synthase B
202 342 Gene3D G3DSA:3.30.870.10 Endonuclease Chain A
108 135 ProSiteProfiles PS50035 Phospholipase D phosphodiesterase active site profile.
286 313 ProSiteProfiles PS50035 Phospholipase D phosphodiesterase active site profile.
392 414 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ81
AlphaFold — — full sequence — Viewing
ColabFold KP13_04336
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.947
3 0.787

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 20.16 0.851
2 7.86 0.417
3 5.34 0.252
4 5.15 0.237
5 3.39 0.121