Protein profile

KP13_04337

Inner membrane protein

Genome: KpKP13

Gene: AHE45570.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQI5
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Amino acids 321
Annotations 1
Features 30
PDB binders 0
Druggability 0.994

Overview

Basic information about this protein and its source genome.

Accession
KP13_04337
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45570.1
Status
annotated
Amino acids
321
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
78.73
DEG E-value
2.69e-177
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.994
Structure A0A0H3GQI5
Pocket Pocket 1
P2Rank 0.917
Structure A0A0H3GQI5
Pocket Pocket 1
ColabFold model
FPocket 0.994 · Pocket 2
P2Rank 0.924 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 65 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
122 144 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
187 205 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13 30 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 295 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region
18 295 InterPro IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD
107 125 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
234 256 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
85 107 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
10 308 PANTHER PTHR34697 PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE
234 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
152 162 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
205 227 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
267 285 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
14 27 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
50 72 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
50 72 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
206 227 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
126 151 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
84 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
28 31 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
228 233 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
73 83 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
286 303 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
281 303 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 31 Phobius SIGNAL_PEPTIDE Signal peptide region
304 321 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
163 186 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
163 185 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQI5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04337
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.994
23 0.512

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.77 0.874
2 7.63 0.403
3 3.14 0.106
4 2.17 0.051
5 1.95 0.041