Protein profile

KP13_03036

CofD family protein

Genome: KpKP13

Gene: AHE45578.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUC1
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Amino acids 301
Annotations 3
Features 13
PDB binders 0
Druggability 0.342

Overview

Basic information about this protein and its source genome.

Accession
KP13_03036
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45578.1
Status
annotated
Amino acids
301
Structure source
AlphaFold + ColabFold
GO
GO:0043743 Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008360 Any process that modulates the surface configuration of a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.342
Structure A0A0H3GUC1
Pocket Pocket 2
P2Rank 0.815
Structure A0A0H3GUC1
Pocket Pocket 1
ColabFold model
FPocket 0.217 · Pocket 5
P2Rank 0.879 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 139 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043743 Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0008360 Any process that modulates the surface configuration of a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
8 299 Hamap MF_00973 Gluconeogenesis factor.
8 299 InterPro IPR010119 Gluconeogenesis factor
1 259 PANTHER PTHR30135 UNCHARACTERIZED PROTEIN YVCK-RELATED
1 259 InterPro IPR010119 Gluconeogenesis factor
9 298 Gene3D G3DSA:3.40.50.10680 -
9 298 InterPro IPR038136 CofD-like domain superfamily
12 286 Pfam PF01933 2-phospho-L-lactate transferase CofD
12 286 InterPro IPR002882 2-phospho-L-lactate transferase CofD
12 258 NCBIfam TIGR01826 uridine diphosphate-N-acetylglucosamine-binding protein YvcK
12 258 InterPro IPR010119 Gluconeogenesis factor
11 294 SUPERFAMILY SSF142338 CofD-like
11 294 InterPro IPR038136 CofD-like domain superfamily
12 295 CDD cd07187 YvcK_like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUC1
AlphaFold — — full sequence — Viewing
ColabFold KP13_03036
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.342

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.96 0.423
2 2.25 0.056