Protein profile

KP13_03014

HlyD-like secretion protein

Genome: KpKP13

Gene: AHE45603.1 Structure source: AlphaFold + ColabFold UniProt A0A060VMI0
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Amino acids 361
Annotations 5
Features 19
PDB binders 0
Druggability 0.719

Overview

Basic information about this protein and its source genome.

Accession
KP13_03014
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45603.1
Status
annotated
Amino acids
361
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
85.18

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.719
Structure A0A060VMI0
Pocket Pocket 1
P2Rank 0.041
Structure A0A060VMI0
Pocket Pocket 1
ColabFold model
FPocket 0.472 · Pocket 12
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
  • GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
183 263 Gene3D G3DSA:2.40.30.170 -
58 182 Gene3D G3DSA:2.40.50.100 -
123 150 Coils Coil Coil
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
86 153 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
32 355 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
32 355 InterPro IPR006143 RND efflux pump, membrane fusion protein
1 18 SignalP_EUK SignalP-noTM SignalP-noTM
45 204 SUPERFAMILY SSF111369 HlyD-like secretion proteins
264 355 Gene3D G3DSA:2.40.420.20 -
1 18 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
21 361 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
60 250 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
60 250 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
11 358 PANTHER PTHR30469 MULTIDRUG RESISTANCE PROTEIN MDTA
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A060VMI0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03014
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.719

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.35 0.015