Protein profile

KP13_03008

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE45609.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUA0
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Amino acids 184
Annotations 2
Features 22
PDB binders 0
Druggability 0.579

Overview

Basic information about this protein and its source genome.

Accession
KP13_03008
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45609.1
Status
annotated
Amino acids
184
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.579
Structure A0A0H3GUA0
Pocket Pocket 1
P2Rank 0.126
Structure A0A0H3GUA0
Pocket Pocket 1
ColabFold model
FPocket 0.808 · Pocket 15
P2Rank 0.124 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 8 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
88 176 Gene3D G3DSA:1.10.10.10 -
88 176 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
117 131 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
117 131 InterPro IPR000792 Transcription regulator LuxR, C-terminal
131 147 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
131 147 InterPro IPR000792 Transcription regulator LuxR, C-terminal
147 159 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
147 159 InterPro IPR000792 Transcription regulator LuxR, C-terminal
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
116 166 Pfam PF00196 Bacterial regulatory proteins, luxR family
116 166 InterPro IPR000792 Transcription regulator LuxR, C-terminal
20 38 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 184 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 19 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
131 158 ProSitePatterns PS00622 LuxR-type HTH domain signature.
131 158 InterPro IPR000792 Transcription regulator LuxR, C-terminal
110 175 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
110 175 InterPro IPR000792 Transcription regulator LuxR, C-terminal
107 170 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
107 170 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
114 171 SMART SM00421 luxrmega5
114 171 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUA0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03008
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.408
5 0.03
6 0.001
2 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.93 0.126
2 1.4 0.014