Protein profile

KP13_02999

Molybdenum transport system permease protein modB

Genome: KpKP13

Gene: AHE45618.1 modB Structure source: AlphaFold + ColabFold UniProt A0A0H3GK73
Export view
Amino acids 229
Annotations 5
Features 30
PDB binders 0
Druggability 0.838

Overview

Basic information about this protein and its source genome.

Accession
KP13_02999
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45618.1 modB
Status
annotated
Amino acids
229
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015098 Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
67.544
DEG E-value
1.49e-105
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.838
Structure A0A0H3GK73
Pocket Pocket 4
P2Rank 0.224
Structure A0A0H3GK73
Pocket Pocket 1
ColabFold model
FPocket 0.812 · Pocket 6
P2Rank 0.199 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 157 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0015098 Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid.
  • GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
20 37 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
71 89 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
136 158 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 213 CDD cd06261 TM_PBP2
12 213 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
116 135 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
49 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
11 214 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
11 214 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 19 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
159 196 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
197 219 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 220 SUPERFAMILY SSF161098 MetI-like
4 220 InterPro IPR035906 MetI-like superfamily
221 229 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
86 108 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 224 FunFam G3DSA:1.10.3720.10:FF:000018 Molybdenum transport system permease
136 158 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 225 PANTHER PTHR30183 MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
49 70 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
197 220 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
26 227 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
26 227 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
38 48 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 221 NCBIfam TIGR02141 molybdate ABC transporter permease subunit
12 221 InterPro IPR011867 Molybdenum transport system permease protein ModB
1 225 Gene3D G3DSA:1.10.3720.10 -
1 225 InterPro IPR035906 MetI-like superfamily
90 115 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GK73
AlphaFold — — full sequence — Viewing
ColabFold KP13_02999
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.838
1 0.577

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.99 0.295
2 1.88 0.037
3 1.5 0.022
4 1.0 0.006