Protein profile

KP13_02997

Transcriptional regulator modE

Genome: KpKP13

Gene: AHE45620.1 modE Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ41
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Amino acids 262
Annotations 5
Features 28
PDB binders 0
Druggability 0.116

Overview

Basic information about this protein and its source genome.

Accession
KP13_02997
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45620.1 modE
Status
annotated
Amino acids
262
Structure source
AlphaFold + ColabFold
GO
GO:0030151 Binding to a molybdenum ion (Mo). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.116
Structure A0A0H3GQ41
Pocket Pocket 5
P2Rank
Structure A0A0H3GQ41
Pocket No pockets
ColabFold model
FPocket 0.423 · Pocket 3
P2Rank 0.039 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0030151 Binding to a molybdenum ion (Mo).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
16 113 NCBIfam TIGR00637 ModE molybdate transport repressor domain
16 113 InterPro IPR003725 Molybdenum-binding protein ModE, N-terminal
1 262 PIRSF PIRSF005763 Txn_reg_ModE
1 262 InterPro IPR016462 Molybdate-dependent transcriptional regulator ModE
2 105 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
2 105 InterPro IPR036390 Winged helix DNA-binding domain superfamily
196 260 ProSiteProfiles PS51866 Mop domain profile.
196 260 InterPro IPR004606 Molybdenum-pterin binding domain
1 107 FunFam G3DSA:1.10.10.10:FF:000154 DNA-binding transcriptional regulator ModE
123 192 SUPERFAMILY SSF50331 MOP-like
123 192 InterPro IPR008995 Molybdate/tungstate binding, C-terminal
184 252 Gene3D G3DSA:2.40.50.100 -
108 183 Gene3D G3DSA:2.40.50.100 -
1 107 Gene3D G3DSA:1.10.10.10 -
1 107 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
123 192 NCBIfam TIGR00638 molybdenum-pterin binding domain
123 192 InterPro IPR004606 Molybdenum-pterin binding domain
124 191 ProSiteProfiles PS51866 Mop domain profile.
124 191 InterPro IPR004606 Molybdenum-pterin binding domain
125 187 Pfam PF03459 TOBE domain
125 187 InterPro IPR005116 Transport-associated OB, type 1
198 258 Pfam PF03459 TOBE domain
198 258 InterPro IPR005116 Transport-associated OB, type 1
200 259 SUPERFAMILY SSF50331 MOP-like
200 259 InterPro IPR008995 Molybdate/tungstate binding, C-terminal
2 178 PANTHER PTHR30432 TRANSCRIPTIONAL REGULATOR MODE
20 83 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
20 83 InterPro IPR000847 Transcription regulator HTH, LysR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ41
AlphaFold — — full sequence — Viewing
ColabFold KP13_02997
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer