Protein profile

KP13_02993

Galactokinase

Genome: KpKP13

Gene: galK AHE45624.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQD1
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Amino acids 383
Annotations 10
Features 39
PDB binders 4
Druggability 0.395

Overview

Basic information about this protein and its source genome.

Accession
KP13_02993
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
galK AHE45624.1
Status
annotated
Amino acids
383
Structure source
AlphaFold + ColabFold
EC
2.7.1.6
GO
GO:0006012 The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016773 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0046835 The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. GO:0004335 Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
43.799
Human E-value
1.2899999999999998e-91
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.395
Structure A0A0H3GQD1
Pocket Pocket 2
P2Rank 0.926
Structure A0A0H3GQD1
Pocket Pocket 1
ColabFold model
FPocket 0.912 · Pocket 1
P2Rank 0.931 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 143 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 9 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

9
  • GO:0006012 The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016773 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
  • GO:0046835 The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.
  • GO:0004335 Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0000287 Binding to a magnesium (Mg) ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

39 records
Show feature table
Start End DB Term Name
3 206 FunFam G3DSA:3.30.230.10:FF:000017 Galactokinase
206 381 SUPERFAMILY SSF55060 GHMP Kinase, C-terminal domain
206 381 InterPro IPR036554 GHMP kinase, C-terminal domain superfamily
26 382 Hamap MF_00246 Galactokinase [galK].
26 382 InterPro IPR022963 Galactokinase, bacterial
122 133 ProSitePatterns PS00627 GHMP kinases putative ATP-binding domain.
122 133 InterPro IPR006203 GHMP kinase, ATP-binding, conserved site
28 39 ProSitePatterns PS00106 Galactokinase signature.
28 39 InterPro IPR019741 Galactokinase, conserved site
2 206 Gene3D G3DSA:3.30.230.10 -
2 206 InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
1 383 PIRSF PIRSF000530 Galactokinase
1 383 InterPro IPR006206 Mevalonate/galactokinase
26 50 PRINTS PR00959 Mevalonate kinase family signature
329 346 PRINTS PR00959 Mevalonate kinase family signature
120 142 PRINTS PR00959 Mevalonate kinase family signature
163 182 PRINTS PR00959 Mevalonate kinase family signature
93 104 PRINTS PR00473 Galactokinase signature
93 104 InterPro IPR000705 Galactokinase
113 131 PRINTS PR00473 Galactokinase signature
113 131 InterPro IPR000705 Galactokinase
264 278 PRINTS PR00473 Galactokinase signature
264 278 InterPro IPR000705 Galactokinase
28 46 PRINTS PR00473 Galactokinase signature
28 46 InterPro IPR000705 Galactokinase
280 362 Pfam PF08544 GHMP kinases C terminal
280 362 InterPro IPR013750 GHMP kinase, C-terminal domain
115 182 Pfam PF00288 GHMP kinases N terminal domain
115 182 InterPro IPR006204 GHMP kinase N-terminal domain
207 382 Gene3D G3DSA:3.30.70.890 -
207 382 InterPro IPR036554 GHMP kinase, C-terminal domain superfamily
6 380 PANTHER PTHR10457 MEVALONATE KINASE/GALACTOKINASE
206 379 FunFam G3DSA:3.30.70.890:FF:000001 Galactokinase
11 59 Pfam PF10509 Galactokinase galactose-binding signature
11 59 InterPro IPR019539 Galactokinase, N-terminal domain
6 383 NCBIfam TIGR00131 galactokinase
6 383 InterPro IPR000705 Galactokinase
2 203 SUPERFAMILY SSF54211 Ribosomal protein S5 domain 2-like
2 203 InterPro IPR020568 Ribosomal protein S5 domain 2-type fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQD1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02993
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.395

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.99 0.894
2 4.9 0.22
3 0.88 0.004

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

64 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
HFK
6Q90
P51570 350.4 Da LogP 3.91 TPSA 79.5 ✓ Ro5 ✓ Clean c1ccc2c(c1)nc(o2)NC3=NC4(CCCCC4)C5=C(N3)CCCC5=O
JHJ
6Q90
P51570 243.3 Da LogP 2.73 TPSA 63.2 ✓ Ro5 ✓ Clean COc1ccc(cc1)NC(=O)Nc2ccncc2
MEV
6MDE
Q8PW39 147.2 Da LogP -1.74 TPSA 80.6 ✓ Ro5 ✓ Clean C[C@@](CCO)(CC(=O)[O-])O
PMV
6MDF
Q8PW39 228.1 Da LogP -0.29 TPSA 124.3 ✓ Ro5 ✓ Clean C[C@@](CCOP(=O)(O)O)(CC(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.