Protein profile

KP13_03251

putative oxaloacetate decarboxylase gamma chain

Genome: KpKP13

Gene: AHE45630.1 Structure source: ColabFold
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Amino acids 69
Annotations 3
Features 13
PDB binders 0
Druggability 0.384

Overview

Basic information about this protein and its source genome.

Accession
KP13_03251
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45630.1
Status
annotated
Amino acids
69
Structure source
ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015081 Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. GO:0036376 The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
76.812
DEG E-value
2.07e-23
Localization
CytoplasmicMembrane
ColabFold pLDDT
79.23

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.384
Structure CB_KP13_03251
Pocket Pocket 1
P2Rank
Structure CB_KP13_03251
Pocket No pockets
ColabFold model
FPocket 0.384 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015081 Enables the transfer of sodium ions (Na+) from one side of a membrane to the other.
  • GO:0036376 The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
18 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
26 69 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 69 Hamap MF_00404 Probable oxaloacetate decarboxylase gamma chain [oadG].
1 69 InterPro IPR023424 Oxaloacetate decarboxylase, gamma chain
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
2 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 65 Pfam PF04277 Oxaloacetate decarboxylase, gamma chain
1 65 InterPro IPR005899 Sodium ion-translocating decarboxylase
1 25 SignalP_EUK SignalP-TM SignalP-TM
1 68 NCBIfam TIGR01195 sodium pump decarboxylases, gamma subunit
1 68 InterPro IPR005899 Sodium ion-translocating decarboxylase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_03251
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.384
2 0.293