Amino acids
283
Annotations
6
Features
27
PDB binders
0
Druggability
0.562
Overview
Basic information about this protein and its source genome.
- Accession
- KP13_03259
- Gene
- AHE45638.1 zitB
- Status
- annotated
- Amino acids
- 283
- Structure source
- AlphaFold + ColabFold
GO
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0006812 The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.
GO:0008324 Enables the transfer of cation from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0005385 Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 48.077
- Human E-value
- 4.43e-07
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- DEG identity (%)
- 42.146
- DEG E-value
- 7.249999999999999e-68
- Localization
- CytoplasmicMembrane
- ColabFold pLDDT
- 87.13
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.562
P2Rank
0.461
ColabFold model
Core conservation
Conserved core gene
Gut microbiome
94 / 4744
genomes with a hit
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
6 GO
Gene Ontology (GO)
6- GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
- GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
- GO:0006812 The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.
- GO:0008324 Enables the transfer of cation from one side of a membrane to the other.
- GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
- GO:0005385 Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
Sequence Features
Domain/signature hits from InterPro and related databases.
27 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 113 | 123 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 152 | 156 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 124 | 151 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 57 | 79 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 263 | PANTHER | PTHR11562 | CATION EFFLUX PROTEIN/ ZINC TRANSPORTER |
| 89 | 111 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 181 | FunFam | G3DSA:1.20.1510.10:FF:000016 | Zinc transporter ZitB |
| 1 | 19 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 262 | NCBIfam | TIGR01297 | cation diffusion facilitator family transporter |
| 1 | 262 | InterPro | IPR002524 | Cation efflux protein |
| 20 | 40 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 41 | 51 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 1 | 182 | Gene3D | G3DSA:1.20.1510.10 | Cation efflux protein transmembrane domain |
| 1 | 182 | InterPro | IPR027469 | Cation efflux transmembrane domain superfamily |
| 124 | 146 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 197 | 261 | SUPERFAMILY | SSF160240 | Cation efflux protein cytoplasmic domain-like |
| 197 | 261 | InterPro | IPR036837 | Cation efflux protein, cytoplasmic domain superfamily |
| 175 | 283 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 15 | 37 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 52 | 76 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 157 | 174 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 77 | 87 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 88 | 112 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 182 | Pfam | PF01545 | Cation efflux family |
| 1 | 182 | InterPro | IPR002524 | Cation efflux protein |
| 1 | 183 | SUPERFAMILY | SSF161111 | Cation efflux protein transmembrane domain-like |
| 1 | 183 | InterPro | IPR027469 | Cation efflux transmembrane domain superfamily |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Legend
High
Medium
Low
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3GQC6
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_03259
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.562 | ||||||
| 27 | 0.448 | ||||||
| 2 | 0.008 | ||||||
| 9 | 0.0 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 9.96 | 0.461 | ||||||
| 2 | 7.58 | 0.336 | ||||||
| 3 | 5.06 | 0.19 | ||||||
| 4 | 2.44 | 0.054 | ||||||
| 5 | 1.95 | 0.034 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 4 | 0.991 | ||||||
| 23 | 0.538 | ||||||
| 1 | 0.001 | ||||||
| 20 | 0.0 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 26.72 | 0.876 | ||||||
| 2 | 2.12 | 0.04 | ||||||
| 3 | 2.09 | 0.039 | ||||||
| 4 | 2.06 | 0.038 | ||||||
| 5 | 1.51 | 0.018 |