Protein target profile

KP13_03263

tetratricopeptide-like helical domain-containing protein

Genome: KpKP13 Gene: AHE45642.1 3D evidence: AlphaFold DB model + ColabFold model UniProt A0A0H3GQ27

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Length 264

Pocket druggability 0.981

Functional annotation 0 EC 5 GO

Target summary

Promising target candidate with multiple supporting evidence streams.

Automated synthesis of the evidence currently loaded. Review the underlying records before prioritizing this protein.

Main supporting evidence

Risks to review

Evidence gaps

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.

Terms and data sources used on this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal Target pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Prioritization evidence

Selectivity, essentiality, structural confidence, conservation, and predicted binding-site evidence.

Off-target risk

Human off-target: No hit
Gut microbiome similarity: 2.2% of screened genomes Lower prevalence suggests narrower overlap with the screened gut microbiome.

Essentiality

Essential (DEG): N
DEG identity (%): 0.0 Higher values support similarity to known essential genes.

Localization

Localization: Periplasmic

Structure confidence

ColabFold pLDDT: 77.53 0-100 confidence; >70 supports local structural interpretation.

Binding-site evidence

AlphaFold DB / UniProt model

The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

FPocket 0.981

Structure A0A0H3GQ27

Pocket Pocket 2

P2Rank 0.315

Structure A0A0H3GQ27

Pocket Pocket 1

ColabFold model

FPocket 0.517 · Pocket 14

P2Rank 0.034 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 103 / 4744 genomes with a hit

Prevalence 2.2%

Cross-references

External database identifiers for this protein, its structures, ligands, and metabolic reactions.

Sequence

UniProt A0A0H3GQ27

Sequence

Primary amino-acid sequence viewer.

MSSNFRHHLLSLSLLVGIAAPWAAFAQAPISSVGSGSVEDRVTQLERISNAHSQLLTQLQQQLSDNQTDIDSLRGQIQENQYQLNQIVERQKQILLQIDSLSSGGGAASGAQAPSSSGDQSAAATSAAPAATSGAPAMTGDANTDYNAAIALVKDASRQDDAMVAFQNFVKKYPDSTYQPNANYWLGQLNYNKGRKDDAAFYFASVVKNYPKSPKAPDAMFKVGVIMQDKGDTAKAKAVYQQVINKFPGTDGAKQAQKRLNALG

Functional annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

GO:0070206 The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits.
GO:0005515 Binding to a protein.
GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.

Sequence domains and features

Domain and signature matches imported from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
1	26	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
56	76	Coils	Coil	Coil
9	20	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
27	264	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35	113	Gene3D	G3DSA:1.20.5.110	-
1	26	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
1	8	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
218	250	Pfam	PF13174	Tetratricopeptide repeat
218	250	InterPro	IPR019734	Tetratricopeptide repeat
142	254	SUPERFAMILY	SSF48452	TPR-like
142	254	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
142	263	FunFam	G3DSA:1.25.40.10:FF:000109	Cell division coordinator CpoB
6	263	Hamap	MF_02066	Cell division coordinator CpoB [cpoB].
6	263	InterPro	IPR034706	Cell division coordinator CpoB
1	26	Phobius	SIGNAL_PEPTIDE	Signal peptide region
107	128	MobiDBLite	mobidb-lite	consensus disorder prediction
37	105	Pfam	PF16331	TolA binding protein trimerisation
37	105	InterPro	IPR032519	YbgF, trimerisation domain
145	260	NCBIfam	TIGR02795	tol-pal system protein YbgF
145	260	InterPro	IPR014162	Cell division coordinator CpoB, C-terminal
142	264	Gene3D	G3DSA:1.25.40.10	Tetratricopeptide repeat domain
142	264	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
160	214	Pfam	PF13432	Tetratricopeptide repeat
21	26	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.

3D structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

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Pocket score High Medium Low

How colors and pocket overlays are used

Uniform protein color marks the displayed model as a single molecular object.

Experimental PDB structures may be colored by chain to distinguish subunits or copies present in the file.

Pocket colors and alpha spheres are evidence overlays for predicted binding cavities; they are not alternative protein chains.

'Alpha spheres' is FPocket's own cavity-shape geometry, imported when available and aligned with the loaded structure.

'Pocket atoms'/'Predicted site atoms' show the pocket's residue atoms instead: P2Rank reports residues rather than alpha spheres, and FPocket falls back to this when alpha-sphere geometry is unavailable or doesn't align.

'No pocket geometry' means neither alpha spheres nor residue-position data could be found for that pocket; the layer just highlights the same residues as 'Nearby residues'.

Pocket details Inspect a specific pocket, or open the full viewer

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #2

0.981

Likely same site as P2Rank 1 1.3 Å 15 shared residues 100% of smaller site

Unusual size

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Surrounding area

Site 2 FPocket #11

0.476

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Surrounding area

Site 3 FPocket #8

0.201

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.315

Likely same site as FPocket 2 1.3 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.102

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Surrounding area

Site 3 P2Rank #3

0.03

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Surrounding area

Site 4 P2Rank #4

0.008

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Surrounding area

Site 5 P2Rank #5

0.003

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Surrounding area

All structural evidence 0 experimental · 2 predicted

Structural evidence

0 + 2

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold DB AF_A0A0H3GQ27	AlphaFold DB	—	—	full sequence	—	Viewing
ColabFold KP13_03263	ColabFold	—	—	full sequence	—	Loaded