Protein profile

KP13_03264

Peptidoglycan-associated lipoprotein

Genome: KpKP13

Gene: pal AHE45643.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQC1
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Amino acids 182
Annotations 3
Features 33
PDB binders 7
Druggability 0.206

Overview

Basic information about this protein and its source genome.

Accession
KP13_03264
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pal AHE45643.1
Status
annotated
Amino acids
182
Structure source
AlphaFold + ColabFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
59.77
DEG E-value
6.95e-67
Localization
OuterMembrane
ColabFold pLDDT
81.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.206
Structure A0A0H3GQC1
Pocket Pocket 4
P2Rank 0.004
Structure A0A0H3GQC1
Pocket Pocket 1
ColabFold model
FPocket 0.391 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 138 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
68 177 PANTHER PTHR30329 STATOR ELEMENT OF FLAGELLAR MOTOR COMPLEX
1 30 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
80 182 NCBIfam TIGR02802 peptidoglycan-associated lipoprotein Pal
80 182 InterPro IPR014169 Peptidoglycan-associated lipoprotein, C-terminal
114 158 ProSitePatterns PS01068 OmpA-like domain.
114 158 InterPro IPR006690 Outer membrane protein, OmpA-like, conserved site
23 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
53 182 FunFam G3DSA:3.30.1330.60:FF:000002 Peptidoglycan-associated lipoprotein
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
80 181 CDD cd07185 OmpA_C-like
80 181 InterPro IPR006665 OmpA-like domain
13 182 Hamap MF_02204 Peptidoglycan-associated lipoprotein [pal].
13 182 InterPro IPR039001 Peptidoglycan-associated lipoprotein
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
27 182 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
69 181 SUPERFAMILY SSF103088 OmpA-like
69 181 InterPro IPR036737 OmpA-like domain superfamily
14 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 28 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
69 182 ProSiteProfiles PS51123 OmpA-like domain profile.
69 182 InterPro IPR006665 OmpA-like domain
112 127 PRINTS PR01021 OMPA domain signature
112 127 InterPro IPR006664 Outer membrane protein, bacterial
82 104 PRINTS PR01021 OMPA domain signature
82 104 InterPro IPR006664 Outer membrane protein, bacterial
127 143 PRINTS PR01021 OMPA domain signature
127 143 InterPro IPR006664 Outer membrane protein, bacterial
81 176 Pfam PF00691 OmpA family
81 176 InterPro IPR006665 OmpA-like domain
53 182 Gene3D G3DSA:3.30.1330.60 -
53 182 InterPro IPR036737 OmpA-like domain superfamily
38 65 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQC1
AlphaFold — — full sequence — Viewing
ColabFold KP13_03264
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.206

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

57 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
5GP
5Y61
Q9I4L6 363.2 Da LogP -2.57 TPSA 206.0 1 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…
7QA
5U1H
P13794 305.3 Da LogP -1.21 TPSA 179.0 1 viol. ✓ Clean C[C@H](C(=O)O)NC(=O)[C@H](CCC[C@H](C(=O)O)N)NC(…
API
5LKW
B4EDC1 190.2 Da LogP -1.02 TPSA 126.6 ✓ Ro5 ✓ Clean C(C[C@H](C(=O)O)N)C[C@@H](C(=O)O)N
C8E
4RLC
P13794 306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO
CXS
5N2C
B4EDC1 221.3 Da LogP 1.19 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCCS(=O)(=O)O
OXL
5N2C
B4EDC1 88.0 Da LogP -3.51 TPSA 80.3 ✓ Ro5 ✓ Clean C(=O)(C(=O)[O-])[O-]
POP
4PWT
A0A2U2GZX0 176.0 Da LogP -2.08 TPSA 129.9 ✓ Ro5 ✓ Clean O[P@@](=O)([O-])O[P@@](=O)(O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.