Protein profile

KP13_03265

Protein tolB

Genome: KpKP13

Gene: AHE45644.1 tolB Structure source: AlphaFold + ColabFold UniProt A0A0H3GK53
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Amino acids 431
Annotations 4
Features 28
PDB binders 0
Druggability 0.654

Overview

Basic information about this protein and its source genome.

Accession
KP13_03265
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45644.1 tolB
Status
annotated
Amino acids
431
Structure source
AlphaFold + ColabFold
GO
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0017038 The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
59.268
DEG E-value
1.1299999999999999e-180
Localization
Periplasmic
ColabFold pLDDT
94.58

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.654
Structure A0A0H3GK53
Pocket Pocket 4
P2Rank 0.75
Structure A0A0H3GK53
Pocket Pocket 1
ColabFold model
FPocket 0.733 · Pocket 3
P2Rank 0.797 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 191 / 4744 genomes with a hit
Normalized 0.04

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0017038 The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
156 429 SUPERFAMILY SSF69304 Tricorn protease N-terminal domain
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
8 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
166 431 FunFam G3DSA:2.120.10.30:FF:000022 Tol-Pal system protein TolB
238 273 Pfam PF07676 WD40-like Beta Propeller Repeat
238 273 InterPro IPR011659 WD40-like beta propeller
282 316 Pfam PF07676 WD40-like Beta Propeller Repeat
282 316 InterPro IPR011659 WD40-like beta propeller
370 397 Pfam PF07676 WD40-like Beta Propeller Repeat
370 397 InterPro IPR011659 WD40-like beta propeller
204 224 Pfam PF07676 WD40-like Beta Propeller Repeat
204 224 InterPro IPR011659 WD40-like beta propeller
166 431 Gene3D G3DSA:2.120.10.30 -
166 431 InterPro IPR011042 Six-bladed beta-propeller, TolB-like
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
23 165 Gene3D G3DSA:3.40.50.10070 -
23 431 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 122 Pfam PF04052 TolB amino-terminal domain
24 122 InterPro IPR007195 TolB, N-terminal
152 397 PANTHER PTHR36842 PROTEIN TOLB HOMOLOG
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
29 162 SUPERFAMILY SSF52964 TolB, N-terminal domain
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
16 428 NCBIfam TIGR02800 Tol-Pal system beta propeller repeat protein TolB
16 428 InterPro IPR014167 Tol-Pal system protein TolB
5 427 Hamap MF_00671 Tol-Pal system protein TolB [tolB].
5 427 InterPro IPR014167 Tol-Pal system protein TolB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GK53
AlphaFold — — full sequence — Viewing
ColabFold KP13_03265
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.654
1 0.55

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.75 0.624
2 4.04 0.161
3 1.51 0.022
4 1.33 0.015