Protein profile

KP13_03266

Protein tolA

Genome: KpKP13

Gene: tolA AHE45645.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU69
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Amino acids 441
Annotations 3
Features 20
PDB binders 0
Druggability 0.203

Overview

Basic information about this protein and its source genome.

Accession
KP13_03266
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
tolA AHE45645.1
Status
annotated
Amino acids
441
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019534 Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. GO:0043213 The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
70.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.203
Structure A0A0H3GU69
Pocket Pocket 25
P2Rank
Structure A0A0H3GU69
Pocket No pockets
ColabFold model
FPocket 0.509 · Pocket 5
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 30 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0019534 Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
  • GO:0043213 The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
61 75 MobiDBLite mobidb-lite consensus disorder prediction
64 281 Coils Coil Coil
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
346 438 Pfam PF06519 TolA C-terminal
346 438 InterPro IPR014161 Tol-Pal system, TolA
353 441 SUPERFAMILY SSF74653 TolA/TonB C-terminal domain
197 237 MobiDBLite mobidb-lite consensus disorder prediction
76 128 MobiDBLite mobidb-lite consensus disorder prediction
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 256 NCBIfam TIGR02794 cell envelope integrity protein TolA
12 256 InterPro IPR014161 Tol-Pal system, TolA
229 440 NCBIfam TIGR02794 cell envelope integrity protein TolA
229 440 InterPro IPR014161 Tol-Pal system, TolA
352 441 Gene3D G3DSA:3.30.1150.10 -
352 440 FunFam G3DSA:3.30.1150.10:FF:000001 Cell envelope integrity protein TolA
32 441 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
61 268 MobiDBLite mobidb-lite consensus disorder prediction
337 354 MobiDBLite mobidb-lite consensus disorder prediction
12 31 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
317 354 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU69
AlphaFold — — full sequence — Viewing
ColabFold KP13_03266
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
25 0.203