Protein profile

KP13_03267

Protein tolR

Genome: KpKP13

Gene: tolR AHE45646.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ25
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Amino acids 142
Annotations 6
Features 14
PDB binders 0
Druggability 0.131

Overview

Basic information about this protein and its source genome.

Accession
KP13_03267
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
tolR AHE45646.1
Status
annotated
Amino acids
142
Structure source
AlphaFold + ColabFold
GO
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.157
DEG E-value
4.1799999999999995e-23
Localization
CytoplasmicMembrane
ColabFold pLDDT
78.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.131
Structure A0A0H3GQ25
Pocket Pocket 8
P2Rank
Structure A0A0H3GQ25
Pocket No pockets
ColabFold model
FPocket 0.201 · Pocket 1
P2Rank 0.006 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 131 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 39 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 140 Hamap MF_02203 Tol-Pal system protein TolR [tolR].
4 140 InterPro IPR014168 Tol-Pal system protein TolR
7 141 PANTHER PTHR30558 EXBD MEMBRANE COMPONENT OF PMF-DRIVEN MACROMOLECULE IMPORT SYSTEM
7 141 InterPro IPR003400 Biopolymer transport protein ExbD/TolR
60 133 FunFam G3DSA:3.30.420.270:FF:000001 Tol-Pal system protein TolR
10 140 Pfam PF02472 Biopolymer transport protein ExbD/TolR
10 140 InterPro IPR003400 Biopolymer transport protein ExbD/TolR
40 142 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
60 133 Gene3D G3DSA:3.30.420.270 -
13 140 NCBIfam TIGR02801 protein TolR
13 140 InterPro IPR014168 Tol-Pal system protein TolR
21 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ25
AlphaFold — — full sequence — Viewing
ColabFold KP13_03267
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer