Protein profile

KP13_03288

lamB family protein

Genome: KpKP13

Gene: AHE45667.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GK15
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Amino acids 247
Annotations 4
Features 10
PDB binders 0
Druggability 0.805

Overview

Basic information about this protein and its source genome.

Accession
KP13_03288
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45667.1
Status
annotated
Amino acids
247
Structure source
AlphaFold + ColabFold
EC
3.5.2.9
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0017168 Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.805
Structure A0A0H3GK15
Pocket Pocket 7
P2Rank 0.889
Structure A0A0H3GK15
Pocket Pocket 1
ColabFold model
FPocket 0.422 · Pocket 2
P2Rank 0.881 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 152 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0017168 Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
3 242 CDD cd10800 LamB_YcsF_YbgL_like
1 244 PANTHER PTHR30292 UNCHARACTERIZED PROTEIN YBGL-RELATED
1 244 InterPro IPR005501 LamB/YcsF/PxpA-like
3 235 Pfam PF03746 LamB/YcsF family
3 235 InterPro IPR005501 LamB/YcsF/PxpA-like
1 246 Gene3D G3DSA:3.20.20.370 Glycoside hydrolase/deacetylase
1 242 SUPERFAMILY SSF88713 Glycoside hydrolase/deacetylase
1 242 InterPro IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
2 240 Hamap MF_00691 5-oxoprolinase subunit A [pxpA].
2 240 InterPro IPR005501 LamB/YcsF/PxpA-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GK15
AlphaFold — — full sequence — Viewing
ColabFold KP13_03288
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.805

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.09 0.795
2 2.73 0.082
3 0.98 0.005