Protein profile

KP13_03306

Ferric uptake regulation protein

Genome: KpKP13

Gene: AHE45685.1 fur Structure source: Experimental + ColabFold UniProt P45599
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Amino acids 150
Annotations 7
Features 14
PDB binders 2
Druggability 0.396

Overview

Basic information about this protein and its source genome.

Accession
KP13_03306
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45685.1 fur
Status
annotated
Amino acids
150
Structure source
Experimental + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0008270 Binding to a zinc ion (Zn).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
96.599
DEG E-value
5.16e-105
Localization
Cytoplasmic
ColabFold pLDDT
88.9

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.396
Structure 5L0P
Pocket Pocket 6
P2Rank
Structure 5L0P
Pocket No pockets
ColabFold model
FPocket 0.506 · Pocket 3
P2Rank 0.3 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 233 / 4744 genomes with a hit
Normalized 0.049

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:1900705 Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
6 134 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
6 134 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 83 Gene3D G3DSA:1.10.10.10 -
1 83 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
85 142 FunFam G3DSA:3.30.1490.190:FF:000001 Ferric uptake regulation protein
10 130 Pfam PF01475 Ferric uptake regulator family
10 130 InterPro IPR002481 Ferric-uptake regulator
85 142 Gene3D G3DSA:3.30.1490.190 -
85 142 InterPro IPR043135 Ferric-uptake regulator, C-terminal domain
3 143 PANTHER PTHR33202 ZINC UPTAKE REGULATION PROTEIN
3 143 InterPro IPR002481 Ferric-uptake regulator
18 133 CDD cd07153 Fur_like
18 133 InterPro IPR002481 Ferric-uptake regulator
1 84 FunFam G3DSA:1.10.10.10:FF:000007 Ferric uptake regulation protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5L0P
X-ray 2.30 Å A
54.0% 3-83
PDBe RCSB PDBj File
Viewing
ColabFold KP13_03306
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.396

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

19 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FLC
4RAY
V6F4Q0 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
MLI
3EYY
Q9K4F8 102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.