Protein profile

KP13_03321

PhoH-like protein

Genome: KpKP13

Gene: AHE45700.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLF1
Export view
Amino acids 348
Annotations 2
Features 9
PDB binders 0
Druggability 0.474

Overview

Basic information about this protein and its source genome.

Accession
KP13_03321
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45700.1
Status
annotated
Amino acids
348
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.046
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
83.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.474
Structure A0A0H3GLF1
Pocket Pocket 25
P2Rank 0.332
Structure A0A0H3GLF1
Pocket Pocket 1
ColabFold model
FPocket 0.418 · Pocket 27
P2Rank 0.34 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1351 / 4744 genomes with a hit
Normalized 0.285

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
4 324 PANTHER PTHR30473 PROTEIN PHOH
325 346 Coils Coil Coil
117 318 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
117 318 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
118 321 Pfam PF02562 PhoH-like protein
118 321 InterPro IPR003714 PhoH-like protein
115 321 Gene3D G3DSA:3.40.50.300 -
115 321 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
115 319 FunFam G3DSA:3.40.50.300:FF:000013 PhoH family ATPase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLF1
AlphaFold — — full sequence — Viewing
ColabFold KP13_03321
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.107
20 0.007
31 0.003
28 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.5 0.332
2 2.36 0.05
3 2.16 0.042
4 1.03 0.006
5 0.74 0.002