Protein profile

KP13_03326

Glutamate/aspartate transport system permease protein gltJ

Genome: KpKP13

Gene: AHE45705.1 gltJ Structure source: AlphaFold + ColabFold UniProt A0A0H3GLE7
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Amino acids 246
Annotations 6
Features 31
PDB binders 0
Druggability 0.919

Overview

Basic information about this protein and its source genome.

Accession
KP13_03326
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45705.1 gltJ
Status
annotated
Amino acids
246
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.86

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.919
Structure A0A0H3GLE7
Pocket Pocket 1
P2Rank 0.205
Structure A0A0H3GLE7
Pocket Pocket 1
ColabFold model
FPocket 0.918 · Pocket 1
P2Rank 0.192 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 127 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
  • GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
18 239 FunFam G3DSA:1.10.3720.10:FF:000021 Glutamate/aspartate ABC transporter, permease protein GltJ
29 228 CDD cd06261 TM_PBP2
29 228 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
51 70 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
29 230 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
29 230 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
71 88 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
47 238 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
47 238 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
66 88 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
200 210 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
18 239 Gene3D G3DSA:1.10.3720.10 -
18 239 InterPro IPR035906 MetI-like superfamily
179 199 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
128 178 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
211 233 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
89 107 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 238 PANTHER PTHR30614 MEMBRANE COMPONENT OF AMINO ACID ABC TRANSPORTER
22 238 InterPro IPR043429 ABC transporter membrane protein permease protein ArtM/GltK/GlnP/TcyL/YhdX-like
108 127 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 132 NCBIfam TIGR01726 ABC transporter permease subunit, His/Glu/Gln/Arg/opine family, N-terminal region
23 132 InterPro IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain
234 246 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
179 196 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 223 SUPERFAMILY SSF161098 MetI-like
24 223 InterPro IPR035906 MetI-like superfamily
211 233 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
108 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 50 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLE7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03326
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.919

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.21 0.242
2 5.05 0.23
3 2.0 0.043
4 1.77 0.032
5 1.69 0.029