Protein profile

KP13_03327

Glutamate/aspartate transport system permease protein gltK

Genome: KpKP13

Gene: AHE45706.1 gltK Structure source: AlphaFold + ColabFold UniProt A0A0H3GPX4
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Amino acids 224
Annotations 6
Features 31
PDB binders 0
Druggability 0.891

Overview

Basic information about this protein and its source genome.

Accession
KP13_03327
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45706.1 gltK
Status
annotated
Amino acids
224
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
92.377
DEG E-value
2.88e-149
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.891
Structure A0A0H3GPX4
Pocket Pocket 2
P2Rank 0.177
Structure A0A0H3GPX4
Pocket Pocket 1
ColabFold model
FPocket 0.781 · Pocket 1
P2Rank 0.211 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 147 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
  • GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
179 197 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
97 116 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
220 224 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3 224 FunFam G3DSA:1.10.3720.10:FF:000006 Glutamate/aspartate ABC transporter, permease protein GltK
153 178 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
34 223 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
34 223 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
20 214 CDD cd06261 TM_PBP2
20 214 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 14 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
197 219 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 210 SUPERFAMILY SSF161098 MetI-like
14 210 InterPro IPR035906 MetI-like superfamily
65 83 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 222 PANTHER PTHR30614 MEMBRANE COMPONENT OF AMINO ACID ABC TRANSPORTER
15 222 InterPro IPR043429 ABC transporter membrane protein permease protein ArtM/GltK/GlnP/TcyL/YhdX-like
15 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
95 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
45 64 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
84 94 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 224 Gene3D G3DSA:1.10.3720.10 -
2 224 InterPro IPR035906 MetI-like superfamily
198 219 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 118 NCBIfam TIGR01726 ABC transporter permease subunit, His/Glu/Gln/Arg/opine family, N-terminal region
13 118 InterPro IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain
113 152 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 216 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
20 216 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
60 82 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPX4
AlphaFold — — full sequence — Viewing
ColabFold KP13_03327
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.891
5 0.636
3 0.442

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.92 0.154
2 2.96 0.096
3 1.02 0.006