Protein profile

KP13_03329

Hemolysin transporter protein hpmB

Genome: KpKP13

Gene: hpmB AHE45708.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTY7
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Amino acids 556
Annotations 4
Features 18
PDB binders 0
Druggability 0.689

Overview

Basic information about this protein and its source genome.

Accession
KP13_03329
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hpmB AHE45708.1
Status
annotated
Amino acids
556
Structure source
AlphaFold + ColabFold
GO
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0098046 A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). GO:0008320 Enables the transfer of a protein from one side of a membrane to the other. GO:0046819 The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
89.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.689
Structure A0A0H3GTY7
Pocket Pocket 1
P2Rank 0.882
Structure A0A0H3GTY7
Pocket Pocket 1
ColabFold model
FPocket 0.825 · Pocket 16
P2Rank 0.915 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0098046 A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc).
  • GO:0008320 Enables the transfer of a protein from one side of a membrane to the other.
  • GO:0046819 The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
75 148 Gene3D G3DSA:3.10.20.310 membrane protein fhac
20 556 PANTHER PTHR34597 SLR1661 PROTEIN
207 520 Pfam PF03865 Haemolysin secretion/activation protein ShlB/FhaC/HecB
207 520 InterPro IPR005565 Haemolysin activator HlyB, C-terminal
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
178 556 Gene3D G3DSA:2.40.160.50 membrane protein fhac: a member of the omp85/tpsb transporter family
25 556 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
74 146 Pfam PF08479 POTRA domain, ShlB-type
74 146 InterPro IPR013686 Polypeptide-transport-associated, ShlB-type
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
149 202 Pfam PF17287 POTRA domain
149 202 InterPro IPR035251 ShlB, POTRA domain
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 556 PIRSF PIRSF029745 FhaC
1 556 InterPro IPR027282 Two partner secretion pathway transporter
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTY7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03329
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.689
32 0.452
3 0.287

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.8 0.762
2 12.76 0.661
3 9.65 0.519
4 2.14 0.05