Protein profile

KP13_03330

putative Filamentous hemagglutinin

Genome: KpKP13

Gene: AHE45709.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLE2
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Amino acids 597
Annotations 0
Features 17
PDB binders 0
Druggability 0.294

Overview

Basic information about this protein and its source genome.

Accession
KP13_03330
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45709.1
Status
annotated
Amino acids
597
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
94.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.294
Structure A0A0H3GLE2
Pocket Pocket 4
P2Rank 0.07
Structure A0A0H3GLE2
Pocket Pocket 1
ColabFold model
FPocket 0.295 · Pocket 1
P2Rank 0.051 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
23 323 SUPERFAMILY SSF51126 Pectin lyase-like
23 323 InterPro IPR011050 Pectin lyase fold/virulence factor
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
30 150 SMART SM00912 Haemagg_act_2a
30 150 InterPro IPR008638 Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain
19 312 Gene3D G3DSA:2.160.20.10 -
19 312 InterPro IPR012334 Pectin lyase fold
23 597 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
48 144 NCBIfam TIGR01901 filamentous hemagglutinin family N-terminal domain
48 144 InterPro IPR008638 Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain
28 275 Pfam PF05860 TPS secretion domain
28 275 InterPro IPR008638 Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLE2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03330
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.294