Protein profile

KP13_03337

hypothetical protein

Genome: KpKP13

Gene: AHE45716.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ21
Export view
Amino acids 105
Annotations 5
Features 11
PDB binders 0
Druggability 0.583

Overview

Basic information about this protein and its source genome.

Accession
KP13_03337
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45716.1
Status
annotated
Amino acids
105
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043023 Binding to a large ribosomal subunit. GO:0042256 The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol. GO:0090071 Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. GO:0017148 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.644
Human E-value
3.22e-15
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
64.762
DEG E-value
1.57e-50
Localization
Cytoplasmic
ColabFold pLDDT
92.0

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.583
Structure A0A0H3GQ21
Pocket Pocket 5
P2Rank 0.078
Structure A0A0H3GQ21
Pocket Pocket 1
ColabFold model
FPocket 0.565 · Pocket 7
P2Rank 0.03 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 164 / 4744 genomes with a hit
Normalized 0.035

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0043023 Binding to a large ribosomal subunit.
  • GO:0042256 The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol.
  • GO:0090071 Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
  • GO:0017148 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 105 Hamap MF_01477 Ribosomal silencing factor RsfS [rsfS].
1 105 InterPro IPR004394 Protein Iojap/ribosomal silencing factor RsfS
2 105 Gene3D G3DSA:3.30.460.10 Beta Polymerase, domain 2
2 105 InterPro IPR043519 Nucleotidyltransferase superfamily
8 105 PANTHER PTHR21043 IOJAP SUPERFAMILY ORTHOLOG
8 105 InterPro IPR004394 Protein Iojap/ribosomal silencing factor RsfS
10 104 Pfam PF02410 Ribosomal silencing factor during starvation
2 105 SUPERFAMILY SSF81301 Nucleotidyltransferase
8 104 NCBIfam TIGR00090 ribosome silencing factor
8 104 InterPro IPR004394 Protein Iojap/ribosomal silencing factor RsfS
2 105 FunFam G3DSA:3.30.460.10:FF:000004 Ribosomal silencing factor RsfS

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ21
AlphaFold — — full sequence — Viewing
ColabFold KP13_03337
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.583
2 0.004
1 0.003
3 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.98 0.078