Protein profile

KP13_03341

Rare lipoprotein A

Genome: KpKP13

Gene: rlpA AHE45720.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPW3
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Amino acids 382
Annotations 8
Features 31
PDB binders 0
Druggability 0.078

Overview

Basic information about this protein and its source genome.

Accession
KP13_03341
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rlpA AHE45720.1
Status
annotated
Amino acids
382
Structure source
AlphaFold + ColabFold
EC
4.2.2.-
GO
GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008932 Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Extracellular
ColabFold pLDDT
73.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.078
Structure A0A0H3GPW3
Pocket Pocket 3
P2Rank 0.081
Structure A0A0H3GPW3
Pocket Pocket 1
ColabFold model
FPocket 0.623 · Pocket 2
P2Rank 0.141 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0008932 Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0000270 The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
305 381 ProSiteProfiles PS51724 SPOR domain profile.
305 381 InterPro IPR007730 Sporulation-like domain
303 381 FunFam G3DSA:3.30.70.1070:FF:000003 Endolytic peptidoglycan transglycosylase RlpA
11 169 Hamap MF_02071 Endolytic peptidoglycan transglycosylase RlpA [rlpA].
11 169 InterPro IPR034718 Endolytic peptidoglycan transglycosylase RlpA
78 166 Pfam PF03330 Lytic transglycolase
78 166 InterPro IPR009009 RlpA-like protein, double-psi beta-barrel domain
214 230 MobiDBLite mobidb-lite consensus disorder prediction
21 382 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
303 381 Gene3D G3DSA:3.30.70.1070 Sporulation related repeat
303 381 InterPro IPR036680 Sporulation-like domain superfamily
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
78 169 FunFam G3DSA:2.40.40.10:FF:000003 Endolytic peptidoglycan transglycosylase RlpA
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 18 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
307 379 Pfam PF05036 SPOR domain
307 379 InterPro IPR007730 Sporulation-like domain
77 160 SUPERFAMILY SSF50685 Barwin-like endoglucanases
77 160 InterPro IPR036908 RlpA-like domain superfamily
78 169 Gene3D G3DSA:2.40.40.10 -
78 169 InterPro IPR036908 RlpA-like domain superfamily
79 168 CDD cd22268 DPBB_RlpA-like
1 375 PANTHER PTHR34183 -
307 379 SUPERFAMILY SSF110997 Sporulation related repeat
307 379 InterPro IPR036680 Sporulation-like domain superfamily
198 230 MobiDBLite mobidb-lite consensus disorder prediction
81 180 NCBIfam TIGR00413 septal ring lytic transglycosylase RlpA family protein
81 180 InterPro IPR012997 Rare lipoprotein A
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPW3
AlphaFold — — full sequence — Viewing
ColabFold KP13_03341
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.78 0.033